FEMH

 

角膜再生與創傷癒合研究團隊

Corneal Regeneration and Wound Healing Research Team

 

歡迎加入我們的研究團隊

更新日期： 2012年2月6日

Congratulations:

目前職缺

博士後研究員一名

具博士學位者，生化、分生、生技、生醫相關系所畢業。

基本條件需求

1.對科學研究具有高度的熱忱及處理事務的責任心。
2.工作勤奮認真，可接受指導並配合計畫進度。
3.曾從事過幹細胞相關研究或動物實驗經驗者尤佳。

待遇(依學經歷以國科會標準支薪)

繳交文件

1.亞東醫院履歷表
2.學歷證件影本
3.應徵博士後研究員者，需附國科會個人研究成果AB表

受理方式(合則約談，恕不退件)

眼科實驗室 陳博士

(E-mail:960887272@mail.femh.org.tw)

一、團隊成員：

團隊主持人　　　張淑雯 副院長 (Dr. Shu-Wen Chang)
眼科醫師　　　　張珮瑤 醫師 (Dr. Pei-Yao Chang)
眼科醫師 　 　　何威廷 醫師 (Dr. Wei-Ting Ho)
博士研究員　　　陳燦麒 博士 (Dr. Tsan-Chi Chen)
碩士研究助理　　蕭欣怡 (Ms. Hsin-I Hsiau)
碩士研究助理　　李智傑 (Mr. Chih-Chieh Lee )
碩士研究生 　　 曾奎諺 (Mr. Kuei-Yen Tseng)

二、研究內容：

　　（一）將初代培養的角膜基質細胞，透過體外培養的方式，尋求促使角質細胞的前趨細胞進行大量增生的生長條件，使其可增生成新的類角膜基質細胞，進而用於臨床上，以重建受傷的角膜。

　　（二）研究於角膜屈光手術過程中，所用的藥物及其濃度對角膜細胞的作用及影響。利用角膜細胞的初步培養方法及分子生物學的相關技術，分析角膜細胞在藥物處理之後所產生的分子反應，藉以瞭解其對手術後角膜在傷口癒合過程可能造成的影響。

三、研究方向：

 

MMC

  • Suppression of Mitomycin C during Cell Migration of Human Corneal Fibroblasts. (Publication #1)

四、研究成果：

A. Publications NCBI

  1. Tsan-Chi Chen, Chien-Hsueh Lai, Jie-Ling Chang, Shu-Wen Chang*. Mitomycin C Retardation of Corneal Fibroblast Migration via Sustained Dephosphorylation of Paxillin at Tyrosine 118. Invest Ophthalmol Vis Sci. (Accepted)
  2. Pei-Yao Chang, Shu-Wen Chang. Corneal Biomechanics, Optic Disc Morphology, and Macular Ganglion Cell Complex in Myopia. J Glaucoma. 2012 Jan 20. [Epub ahead of print]
  3. Tai Yuan Su, Chen Kerh Hwa, Po Hsuan Liu, Ming Hong Wu, David O. Chang, Po Fang Su, Shu Wen Chang, and Huihua Kenny Chiang. Noncontact detection of dry eye using a custom designed infrared thermal image system. J Biomed Opt. 2011 Apr;16(4):046009.
  4. San-Fang Chou, Chien-Hsien Lin, Shu-Wen Chang.* Povidone–iodine application induces corneal cell death through fixation. Br J Ophthalmol. 2011 Jan;95(2):277-83.
  5. Tsan-Chi Chen, Shu-Wen Chang.*
  6. Shu-Wen Chang,* San-Fang Chou, Shuen-Yuen Yu. Dexamethasone modulates mitomycin C-related inflammatory cytokine expression in corneal fibroblasts. Wound Repair Regen 2010 Jan-Feb; 18(1);59-69.
  7. Pei-Yao Chang, Shu-Wen Chang,* Jiun-Yi Wang. Assessment of corneal biomechanical properties and intraocular pressure with Ocular Response Analyzer in childhood myopia. Br J Ophthalmol. 2010 Jul;94(7):877-81. Epub 2009 Oct 14.
  8. Shu-Wen Chang,* Chin-Yen Yu, Daniel P. Chen. Comparison of intraocular lens power calculation by IOLMaster in phakic and eyes with hydrophobic acrylic lenses. Ophthalmology 2009 Jul; 116(7): 1136-42.
  9. Chao-Yu Hu, Elsa Mei, Shu-Wen Chang. Widen the anterior chamber angles of a primary angle closure patient with Argon laser peripheral iridoplasty-a case report. Acta Soc Ophthalmol Sinicae 2008 47(3): 246-51.
  10. Po-Fang Su, Andy Y. Lo, Chao-Yu Hu, Shu-Wen Chang.* Anterior chamber depth measurement in phakic and pseudophakic eyes. Optom Vis Sci. 2008 Dec;85(12):1193-200.
  11. Shu-Wen Chang,* San-Fang Chou, Jia-Ling Chuang. Mitomycin C potentiates ultraviolet-related cytotoxicity in corneal fibroblasts. Cornea. 2008 Jul;27(6):686-92.
  12. Jia-Kang Wang, Chao-Yu Hu, Shu-Wen Chang. Intraocular lens power calculation using the IOLMaster and various formulas in eyes with long axial length. J Cataract Refract Surg. 2008 Feb;34(2):262-7.
  13. Shu-Wen Chang, * San-Fang Chou, Jia-Ling Chuang. Mechanical corneal epithelium scraping and ethanol treatment up-regulate cytokine gene expression differently in rabbit cornea. J Refract Surg. 2008 Feb;24(2):150-9.
  14. San-Fang Chou, Shu-Wen Chang,* Jia-Ling Chuang. Mitomycin C Upregulates IL-8 and MCP-1 Chemokine Expression via Mitogen-Activated Protein Kinases in Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2007 May;48(5):2009-16.
  15. Daniel P. Chen; Shih-Chen Chen; Shu-Wen Chang. Ocular Thelaziasis Manifested As Conjunctivitis –a Case Report. Acta Soc Ophthalmol Sinicae. 2007;46(1):46-50.
  16. Shu-Wen Chang,* San-Fang Chou, Yao-Horng Wang. Ethanol treatment induces significant cell death in porcine corneal fibroblasts. Cornea. 2006 Oct;25(9):1072-9.
  17. Shu-Wen Chang,* Zei-Lun Huang. Oral cimetidine adjuvant therapy for recalcitrant, diffuse conjunctival papillomatosis. Cornea. 2006 Jul;25(6):687-90.
  18. Pei-Ching Lai, Jia-Kang Wang, Andy Y. Lo, Shu-Wen Chang. Traumatic Evulasion of the Eyeball: a Case Report. Acta Soc Ophthalmol Sinicae. 2006;45(1):30-5.
  19. Shu-Wen Chang, Gwo-Jyh Chang, Ming-Jai Su. Change of potassium current density in rabbit corneal epithelial cells during maturation and cellular senescence. J Formos Med Assoc. 2006 Jan;105(1):7-16.
  20. Shu-Wen Chang,* Yao-Horng Wang; Jong-Hwei Su Pang. The effects of epithelial viability on stromal keratocyte apoptosis in porcine corneas stored in Optisol-GS. Cornea. 2006 Jan;25(1):78-84.
  21. Wang JK, Lai PC, Yang CM, Chen CH, Chang SW. Circumscribed choroidal hemangioma in a Chinese patient treated using transpupillary thermotherapy: a case report. Kaohsiung Med Sci 2005;21:433-7.
  22. Shu-Wen Chang.* Corneal keratocyte apoptosis following topical intraoperative mitomycin C in rabbits. J Refract Surg. 2005 Sep-Oct;21(5):446-53.
  23. Huang ZL, Chen YF, Chang SW, Lin KK, Hsiao CH. Recurrent Alcaligenes xylosoxidans keratitis. Cornea. 2005 May;24(4):489-90.
  24. Hung-Chiao Chen, Shu-Wen Chang,* Shiu-Feng Huang. Adjunctive treatment with interferon alpha-2b may decrease the risk of papilloma-associated conjunctival intraepithelial neoplasm recurrence. Cornea 2004 Oct;23(7):726-9. Review.
  25. Shu-Wen Chang.* Early corneal edema following topical application of mitomycin-C. J Cataract Refract Surg 2004;30(8):1742-50.
  26. Shu-Wen Chang,* Ai-Chuen Chou, Chang-Hao Yang, Por-Tying Hung. IOL decentration increases with patient’s age. Acta Soc Ophthalmol Sinicae, 2003;42:110-9.
  27. Wan-Ya Su, Shu-Wen Chang,* Shiu-Feng Huang. Amniotic membrane transplantation for vitamin A deficiency related corneal perforation. Ophthalmic Surg Lasers Imaging. 2003 Mar-Apr;34(2):140-4.
  28. Li-Chin Wei, Shu-Wen Chang.* Bilateral retinal hemorrhages following ALK. Ophthalmic Surg Lasers 2002 Jan-Feb;33(1):54-7.
  29. Shu-Wen Chang,* Chi-Jen Chang. Delayed Tear Clearance in Contact Lens Associated Papillary Conjunctivitis. Curr Eye Res 2001;22(4):253-7.
  30. Shu-Wen Chang,* I-Lun Tsai, Fung Rong Hu, Luke LL Lin, Yung-Feng Shih. The corneas in young myopic adults. Br J Ophthalmol 2001;85(8):916-20.
  31. Chi-Chin Sun, Shu-Wen Chang, * Ray RF Tsai. Traumatic corneal perforation with epithelial ingrowth after laser in situ keratomileusis. Arch Ophthalmol 2001;119(6):907-9.
  32. Shu-Wen Chang,* Fung-Rong Hu, Luke Long-Kuang Lin. Effects of contact lenses on corneal endothelium - a morphological and functional study. Ophthalmologica 2001;215:197-203.
  33. Chang SW,* Ashraf FM, Azar DT.Wound healing patterns following perforation sustained during laser in situ keratomileusis. J Formos Med Assoc 2000;99(8):635-41.
  34. Chang SW, Chi RF,Wu CC, Su MJ. Benzalkonium chloride and gentamicin cause a leak in corneal epithelial cell membrane. Exp Eye Res 2000 Jul;71(1):3-10.
  35. Hu FR, Tsai AC,Wang IJ, Chang SW. Outcomes of penetrating keratoplasty with imported donor corneas. Cornea 1999 Mar;18(2):182-7.
  36. Shu-Wen Chang, Alan Benson, Dimitri T. Azar. Corneal light scattering with stromal reformation after laser in situ keratomileusis and photorefractive keratectomy. J Cataract Refrac Surg 1998;24(8): 1064-9.
  37. Fung-Rong Hu, Chau-Yi Tan, Shu-Wen Chang, Huai-Wen Chang. Analysis of Corneal TopographyAfter Excimer Laser Photorefractive Keratectomy. J Formos Med Assoc 1998;97:159-64.
  38. Yu JH, Hu FR, Chang SW,Wang IJ. Excimer laser photorefractive keratectomy for myopia. J Formos Med Assoc. 1996 Mar;95(3):225-30.
  39. Shu-Wen Chang,* Fung-Rong Hu, Ping-Kang Hou. Corneal Epithelial Recovery Following Photorefractive Keratectomy. Br J Ophthalmol 1996;80:663-8.
  40. Jeng-Horng Yu, Fung-Rong Hu, Shu-Wen Chang, I-JongWang. Excimer Laser Photorefractive Keratectomy for Myopia. J Formos Med Assoc 1996;95:225-30.
  41. An-Chung Tsai, Meng-Chun Tseng, Shu-Wen Chang, Fung-Rong Hu. Clinical Evaluation of Ciprofloxacin Ophthalmic Solution in the Treatment of Refractory Bacterial Keratitis. J Formosan Med Assoc 1995;94:760-4.
  42. Shu-Wen Chang, * Hui-Chuan Hsu, Fung-Rong Hu, Muh-Shy Chen. Corneal Autofluorescence and Epithelial Barrier Function in Diabetic Patients. Ophthalmic Res 1995;27:74-9.
  43. Chau-Chung Wu, Shu-Wen Chang,* Muh-Shy Chen, Yuan-Teh Lee. Early Change of Vascular Permeability in Hypercholesterolemic Rabbits. Arterioscl Thromb Vas 1995; 15:529-33.
  44. Chen-Kuo Tsen, Shu-Wen Chang, Fung-Rong Hu. Acyclovir Treatment for Linear Corneal Endotheliitis on Grafted Corneas. Cornea.1995;14(3):311-5.
  45. Shu-Wen Chang,* Fung-Rong Hu. Corneal epithelial barrier function following penetrating keratoplasty. Ophthalmic Res 1994;26:283-9.
  46. Hwang Wei-Jen, Fung-Rong Hu, Shu-Wen Chang. Clinicopathologic Study of Gore-Tex Patch Graft in Corneoscleral Surgery. Cornea. 1994;13(1):82-6.
  47. Shu-Wen Chang,* Meng-Whai Tsai, Fung-Rong Hu. Deep Alternaria Keratomycosis with Intraocular Extension. Am J Ophthalmology 117(4):544-5;1994.
  48. Shu-Wen Chang,* Fung-Fong Hu. Changes in Corneal Autofluorescence and Corneal Epithelial Barrier Function with Aging. Cornea. 12(6):493-9;1993.
  49. Sanni Chen, Shu-Wen Chang,* Fung-Rong Hu. Ocular Complications in Generalized Erythroderma. Acta Soc Ophthalmol Sinicae 1992;31:470-4.
  50. Shu-Wen Chang,* Luke Long-Kuang Lin. Study of Refractive Status on Strabismic Patients in Taiwan. Acta Soc Ophthalmol Sinicae 1992;31: 236-2.
  51. Shu-Wen Chang,* Por-Tying Hung. Effect of carteolol on intraocular pressure elevation following laser iridotomy. J Clinical Laser Med Surg 1991; Aug: 259-63.
  52. Shu-Wen Chang,* Muh-Shy Chen, Ping-Kang Hou. Conjunctival Concretions: Polarized Microscopic Histopathologic and Ultrastructural Studies. Archives of Ophthalmology 1990; 108(3):405-7.
  53. Shu-Wen Chang,* Muh-Shy Chen, Chu-Fu Lan. Crystalline Tapetoretinal Dystrophy. Acta Soc Ophthalmol Sinicae 1989; 28:775-80.

 

B. Conference Papers

  1. Shu-Wen Chang, Yao-Lin Chen, Chin-Yen Yu, Yio-Wha Shau. Impact of Wound Size and Ocular Structure on Surgically Induced Astigmatism after Cataract Surgery. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, Nov 26-27, 2011, Taipei, Taiwan, R.O.C.
  2. Shu-Wen Chang, Tsan-Chi Chen. Mitomycin C-Inducing Assembly of Nuclear Fibulin-1 Protein in Human Corneal Fibroblasts. The 2011 Annual Meeting of the Ophthalmological Society of the Republic of China, Taipei, Taiwan, R.O.C. Nov 26-27, 2011.
  3. Wei-Ting Ho, Shu-Wen Chang. Accuracy of postoperative autorefraction after refractive and diffractive multifocal intraocular lens implantation. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, Nov 26-27, 2011, Taipei, Taiwan, R.O.C.
  4. Pei-Yuan Su, Shu-Wen Chang. In vitro comparison of glistening formation in different intraocular lenses by temperature change. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, Nov 26-27, 2011, Taipei, Taiwan, R.O.C.
  5. Yu-Hsien Chien, Pei-Yao Chang, Jia-Kang Wang, Chang-Hao Yang, Shu-Wen Chang. Short-term efficacy of intravitreal ranibizumab for treating neovascular age-related macular degeneration. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, Nov 26-27, 2011, Taipei, Taiwan, R.O.C.
  6. Tsu-Hua Chen, Jia-Kang Wang, Ting-Kuang Chao, Shu-Wen Chang. Compressive optic neuropathy caused by posterior ethmoid sinus cholesterol granuloma – A Case Report. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, Nov 26-27, 2011, Taipei, Taiwan, R.O.C.
  7. Chuan-Fang Liu, Elsa Mai, Pei-Yuang Su, Shu-Wen Chang. Hyperostosis, The Early Specific Presentation of Orbit Meningioma en Plaque – A Case Report. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, Nov 26-27, 2011, Taipei, Taiwan, R.O.C.
  8. Fang-Ting Chen, Shu-Wen Chang. Leptomeningeal carcinomatosis causing severe papilledema – A case report. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, Nov 26-27, 2011, Taipei, Taiwan, R.O.C.
  9. Chuan-Fang Liu, Jia-Kang Wang, Pei-Yuang Su, Shu-Wen Chang. Sino-orbital-cerebral Mucomycosis Presented with Unilateral Orbital Apex Syndrome, a Case Report. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, Nov 26-27, 2011, Taipei, Taiwan, R.O.C.
  10. Shu-Wen Chang*, Tsan-Chi Chen, Chuan-Long Hsu, Chien-Hsueh Lai. Mitomycin C Retards Corneal Fibroblast Cell Migration via Recruitment of FAK/Paxillin Complexes to Lamellipodial Matrix Metallopeptidase-9. Poster presented at the annual meeting of the Association of Research in Vision and Ophthalmology, May 1-5, 2011. Ft. Lauderdale, Florida, U.S.A.
  11. Tsan-Chi Chen, Chuan-Long Hsu, Hsiao-Wen Roan, Shu-Wen Chang*. Suppression of Mitomycin C on Gene Expression of Human Corneal Fibroblasts via Nuclear Fibulin-1 Assembly. The 25th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, R.O.C., Mar 19-20, 2011.
  12. Tsan-Chi Chen, Hsin-I Hsiau, Chien-Hsueh Lai, Shu-Wen Chang*. Enhancement of ABCG2 in Human Corneal Fibroblasts using In Vitro Stimulating Culture System. The 25th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, R.O.C., Mar 19-20, 2011.
  13. Wei-Ting Ho, Shu-Wen Chang*. Intracameral moxifloxacin for endophthalmitis after cataract surgery- a case series. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December, 2010, Taipei, Taiwan, R.O.C.
  14. Yu-Hsien Chien, Jia-Kang Wang, Shu-Wen Chang. Hyperviscosity-related retinopathy in a patient with chronic myelogenous leukemia – a case report. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December, 2010, Taipei, Taiwan, R.O.C.
  15. Pei-Jen Chen, Chuan Fang Liu, Shu-Wen Chang. Bilateral inferior oblique weakening surgery for ocular torticollis. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December, 2010, Taipei, Taiwan, R.O.C.
  16. Wei-Ting Ho, San-Fong Chou, Tsan-Chi Chen, Shu-Wen Chang*. Dexamethasone prevents excessive cell death and reduces inflammation induced by mitomycin-C treatment of human Tenon’s capsule fibroblasts. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December, 2010, Taipei, Taiwan, R.O.C.
  17. Shu-Wen Chang*, Tsan-Chi Chen, Chien-Hsueh Lai. Mitomycin C Interferes in Matrix Metallopeptidase-9-Dependent Lamellipodial Extension of Corneal Fibroblasts. The 2010 Annual Meeting of the Ophthalmological Society of the Republic of China, Taipei, Taiwan, R.O.C. Dec 4-5, 2010.
  18. Shu-Wen Chang*, Tsan-Chi Chen, Pei-Ting Jian. Moxifloxacin Suppresses Corneal Fibroblast Cell Migration via Paxillin Dephosphorylation. The 2010 Annual Meeting of the Ophthalmological Society of the Republic of China, Taipei, Taiwan, R.O.C. Dec 4-5, 2010.
  19. Shu-Wen Chang*, Tsan-Chi Chen, Ting-Yi Wang, San-Fang Chou. Moxifloxacin Suppresses Myofibroblast Differentiation via Blocking TGF-betaRI on Corneal Fibroblasts. Poster presented at the annual meeting of the Association of Research in Vision and Ophthalmology, May, 2010. Ft. Lauderdale, Florida, U.S.A.
  20. Tsan-Chi Chen, Ting-Yi Wang, San-Fang Chou, Pei-Ting Jian, Shu-Wen Chang*. Moxifloxacin-Causing Suppression of Corneal Myofibroblast Differentiation via Blocking TGF-βRI Expressions. Poster presented at the 25th Joint Annual Conference of Biomedical Science, March, 2010, Taipei, Taiwan, R.O.C.
  21. Tsan-Chi Chen, Ting-Yi Wang, Chien-Hsueh Lai, Jie-Ling Chang, Shu-Wen Chang*. Mitomycin C-Retarding Corneal Fibroblast Migration via Dephosphorylation of Paxillin at Tyrosine 118. Poster presented at the 25th Joint Annual Conference of Biomedical Science, March, 2010, Taipei, Taiwan, R.O.C.
  22. San-Fang Chou, Shih-Yun Li, Tsan-Chi Chen, Shu-Wen Chang*. Culture Medium Influence IL-1b-Induced MMP-9 Expression in Human Corneal Epithelial Cells. Poster presented at the 25th Joint Annual Conference of Biomedical Science, March 2010, Taipei, Taiwan, R.O.C.
  23. Shu-Wen Chang*, Tsan-Chi Chen, Ting-Yi Wang, Fang-Yi Lin. Moxifloxacin Suppresses Alpha Smooth Muscle Actin Expression in Corneal Fibroblasts. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, November, 2009, Taipei, Taiwan, R.O.C.
  24. Andy Y. Lo, Po-Fang Su, Pei-Jen Chen, Shu-Wen Chang*. Repeatability of Ocular Response analyzer in healthy adults. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, November, 2008, Taipei, Taiwan, R.O.C.
  25. Shu-Wen Chang*, Tsan-Chi Chen, Ting-Yi Wang, Jie-Ling Chang. Mitomycin C Inhibits Corneal Fibroblast Migration through Dephosphorylation of FAK/Paxillin Signaling. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, November, 2008, Taipei, Taiwan, R.O.C.
  26. Shu-Wen Chang*, Tsan-Chi Chen, Ting-Yi Wang, Fang-Yi Lin. Mitomycin C-Treated Corneal Fibroblasts Regulate Corneal Epithelial Migration through HGF Secretion. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, November, 2008, Taipei, Taiwan, R.O.C.
  27. Wei-Ting Ho, San-Fong Chou, Shu-Wen Chang*. Mitomycin-C treatment induces inflammatory cytokines expression in human Tenon’s capsule fibroblasts. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, November, 2008, Taipei, Taiwan, R.O.C.
  28. Po-Fang Su, Andy Y. Lo, Pei-Jen Chen, Shu-Wen Chang*. The Agreement of Pupil Size Measured byAS-OCT and Pentacam. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, November, 2008, Taipei, Taiwan, R.O.C.
  29. Pei-Yuang Su, Yao-Peng Shu, Shu-Wen Chang*. Orbital Metastatic Cancer of Unknown Primary - a case report. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, November, 2008, Taipei, Taiwan, R.O.C.
  30. Shu-Wen Chang*, San-Fang Chou, Chien-Hsin Lin. Povidone–iodine caused human corneal stromal and epithelial cell death through fixation. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, November, 2008, Taipei, Taiwan, R.O.C
  31. Pei-yao Chang, Shu-Wen Chang*. Assessment of corneal biomechanical properties and intraocular pressure with Ocular Response Analyzer in childhood myopia. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, November, 2008, Taipei, Taiwan, R.O.C.
  32. Andy Y. Lo, Po-Fang Su, Jheng-Yu Huang, Shu-Wen Chang*. Central Corneal Thickness Measurement by Fourier Domain Optical Coherence Tomography, Ocular Response Analyzer and Ultrasound Pachymetry. Paper presented at the annual meeting of the European Society of Cataract and Refractive Surgeons, Sep. 2008. Berlin, German.
  33. Shu-Wen Chang*, Chin-Yen Yu, Daniel P. Chen. Comparison of intraocular power calculation by IOLMaster measurement in phakic and pseudophakic eyes. Poster presented at the annual meeting of the European Society of Cataract and Refractive Surgeons, Sep. 2008. Berlin, German.
  34. Po-Fang Su; Andy Y. Lo; Chao-Yu Hu; Shu-Wen Chang*. The Limitation of Anterior chamber Depth Measurement with Scheimflug Imaged Based Device in Pseudophakic Eyes. Poster presented at the annual meeting of World Ophthalmology Congress, June, 2008 Hong Kong.
  35. Andy Y. Lo, Po-Fang Su, Daniel P. Chen, Shu-Wen Chang*. Evaluating the association between corneal curvature and cycloplegia in young adults. Poster presented at the annual meeting of World Ophthalmology Congress, June, 2008 Hong Kong.
  36. Shu-Wen Chang*, San-Fang Chou, Jie-Ling Chang, Chien-Hsin Lin, Shuen-Yuen Yu. Mitomycin C modulates MMPs and TIMP Expression in Corneal Fibroblasts. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December, 2007, Taipei, Taiwan, R.O.C.
  37. Shu-Wen Chang*, San-Fang Chou, Jia-Ling Chuang. Mitomycin C Inhibits Alpha-Smooth Muscle Actin Expression in Corneal Fibroblasts via ERK-1/2. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December, 2007, Taipei, Taiwan, R.O.C.
  38. Por-Fong Su, Andy Y. Lo, Daniel P. Chen, Shu-Wen Chang*. Comparison of central and peripheral corneal pachymetry measurements using AS-OCT and Pentacam. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December, 2007, Taipei, Taiwan, R.O.C.
  39. Andy Y. Lo, Por-Fong Su, Daniel P. Chen, Shu-Wen Chang*. Evaluating the association between corneal curvature and ciliary muscle contraction in young adults using Pentacam, AS-OCT and IOLMaster. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December, 2007, Taipei, Taiwan, R.O.C.
  40. Shu-Wen Chang*, Por-Fong Su, Andy Y. Lo, Chao-Yu Hu. The Limitation of Anterior Chamber Depth Measurement in Pesudophakic Eyes with Different Imaging Devices. Poster presented at the annual meeting of the European Society of Cataract and Refractive Surgeons, Sep. 2007. Stockholm, Sweden.
  41. Shu-Wen Chang*, San-Fang Chou, Jia-Ling Chuang. Mitomycin C Upregulates IL-8 and MCP-1 Chemokine Expression via Mitogen-Activated Protein Kinases in Corneal Fibroblasts. Poster presented at the annual meeting of the Association of Research in Vision and Ophthalmology, May, 2007. Ft. Lauderdale, Florida, U.S.A.
  42. Chao-Yu Hu, Shih-Chen Chen, Shu-Wen Chang*. Effects of topical tropicamide on the anterior segment. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, April, 2007, Taipei, Taiwan, R.O.C.
  43. Chao-Yu Hu, Elsa Mai, Shu-Wen Chang*. Primary angle-closure treated with argon laser peripheral iridoplasty case report. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, April, 2007, Taipei, Taiwan, R.O.C.
  44. 吳嘉敏*、廖述朗、張淑雯*、蘇姵元. A case of sudoriferous cyst of orbit. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, April, 2007, Taipei, Taiwan, R.O.C.
  45. Shu-Wen Chang*, San-Fang Chou, Jia-Ling Chuang. Mitomycin C Upregulates IL-8 and MCP-1 Chemokine Expression via Mitogen-Activated Protein Kinases in Corneal Fibroblasts. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2006, Taipei, Taiwan, R.O.C.
  46. Shu-Wen Chang*, San-Fang Chou, Jia-Ling Chuang. Mitomycin C Aggravates UV-related Cytotoxicity in Corneal Fibroblasts. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2006, Taipei, Taiwan, R.O.C.
  47. Po-Fang Su; Andy Y. Lo; Shu-Wen Chang*. Blue Blocker Intraocular Lens Interferes with Anterior Chamber Depth Evaluation in Scheimpflug Image Based Device. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2006, Taipei, Taiwan, R.O.C.
  48. Shu-Wen Chang*, San-Fang Chou. Effect of Ethanol Treatment on Rabbit Corneas. Poster presented at the annual meeting of the Association of Research in Vision and Ophthalmology, Apr, 2006. Ft. Lauderdale, Florida, U.S.A.
  49. Shu-Wen Chang*. Povidone-iodine Application Induces Epithelium and Stromal Keratocytes Apoptosis in Pig Corneas. Poster presented at the annual meeting of the American Society of Cataract and Refractive Surgeons, March, 2006. San Francisco, California, U.S.A.
  50. Po-Fang Su; Andy Y. Lo; Shu-Wen Chang*. Complete Remission of Intraocular Metastatic Breast Cancer with Chemotherapy: Case Report. Poster presented at the Regional Meeting of the Ophthalmological Society of the Republic of China, April 2006, Kaoshiung, Taiwan, R.O.C.
  51. Andy Y. Lo, Por-Fong Su, Shu-Wen Chang*. Changes of anterior and posterior corneal surfaces induced by mydriasis in post-LASIK cornea. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2005, Taipei, Taiwan, R.O.C.
  52. Shu-Wen Chang*, San-Fang Chou. UV changes inflammatory cytokine expression of corneal fibroblast. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2005, Taipei, Taiwan, R.O.C.
  53. Daniel P. Chen,Andy Y. Lo, Shu-Wen Chang*. Cataract surgery induced astigmatism between folding and Injection System. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2005, Taipei, Taiwan, R.O.C.
  54. Por-Fong Su, Andy Y. Lo, Shu-Wen Chang*. Comparative estimation of anterior chamber depth and axial length by IOLMater, Pentacam, and ultrasonography. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2005, Taipei, Taiwan, R.O.C.
  55. Shu-Wen Chang*, San-Fang Chou, Yao-HorngWang. Mitomycin C Changes the Inflammatory Cytokines Expression of Porcine Corneal Fibroblasts. Poster presented at the annulal meeting of the Association of Research in Vision and Ophthalmology, Ft. Lauderdale, Florida, U.S.A. Apr, 2005.
  56. Daniel P. Chen, Shu-Wen Chang, Chii-Wann Lin, Andy Y. Lo. Foldable IOL Crack and Surface Scratch - A Report of Five Cases. Poster presented at the Local Meeting of the Ophthalmological Society of the Republic of China, May 2005, Taichung, Taiwan, R.O.C..
  57. Shu-Wen Chang*, San-Fang Chou, Chin-Yi Chen. Mitomycin C changes the Expression of Inflammatory Cytokines in Pig Corneal Fibroblasts. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, October 2004, Taipei, Taiwan, R.O.C.
  58. Shu-Wen Chang*, San-Fang Chou, Chin-Yi Chen. Ultraviolet B Irradiation Increased the Expression of Inflammatory Cytokines in Pig Corneal Fibroblasts. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, October 2004, Taipei, Taiwan, R.O.C.
  59. Shu-Wen Chang*, San-Fang Chou, Chin-Yi Chen Ethanol Treatment Induced Significant Cell Death in Pig Corneal Fibroblasts. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, October 2004, Taipei, Taiwan, R.O.C.
  60. Andy Y. Lo, Shu-Wen Chang*. UV Exposure Related Transient Corneal curvature Change –Case Report. Poster presented at the Local Meeting of the Ophthalmological Society of the Republic of China, April 2004, Taichung, Taiwan, R.O.C.
  61. Shu-Wen Chang*. Corneal keratocyte change following topical mitomycin C application. Poster presented at the annual meeting of the Association of Research in Vision and Ophthalmology, Ft. Lauderdale, Florida, U.S.A. Apr, 2004.
  62. Shu-Wen Chang*. Corneal Keratocyte Apoptosis Following Topical Mitomycin C Application. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2003, Taipei, Taiwan, R.O.C.
  63. Shu-Wen Chang*. Change of Corneal Epithelium and Stromal Keratocytes after Betadine Treatment. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2003, Taipei, Taiwan, R.O.C.
  64. Shu-Wen Chang*. Interleukin-8 and Monocyte Chemoattractant Protein-1 after Topical Alcohol Treatment in Rabbit Cornea. Paper presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2003, Taipei, Taiwan, R.O.C.
  65. Shu-Wen Chang*, Chau-ChungWu, Long-Sheng Lu. Dietary cholesterol withdrawal regresses the iridic vascular permeability change in rabbits. Poster presented at the Annual Meeting of the Ophthalmological Society of the Republic of China, December 2003, Taipei, Taiwan, R.O.C
  66. Shin-Hong Lin, Shu-Wen Chang*. Therapeutic Penetrating keratoplasty in the treatment of perforated fungal corneal ulcer—A case report. Paper presented at the Regional Meeting of the Ophthalmological Society of the Republic of China, April 2003, Tainan, Taiwan, R.O.C.
  67. Shu-Wen Chang*, J.-H.S. Pang. Effect of Mitomycin C on Corneal Endothelium Following Topical Application. Poster presented at the annual meeting of the Association of Research in Vision and Ophthalmology, Ft. Lauderdale, Florida, U.S.A. May 1-6, 2003.
  68. Shu-Wen Chang*. Viability and Apoptosis of Pig Stromal Keratocytes in Corneal Preservation Medium. Paper presented at the 43th Annual Meeting of the Ophthalmological Society of the Republic of China, December 2002, Taipei, Taiwan, R.O.C.
  69. Shu-Wen Chang*. Interleukin-8 and Monocyte Chemoattractant Protein-1 in Persistent Corneal Epithelial Defect. Paper presented at the 43th Annual Meeting of the Ophthalmological Society of the Republic of China, December 2002, Taipei, Taiwan, R.O.C.
  70. Shu-Wen Chang*. Effect of Mitomycin C on Corneal Endothelium Following Topical Application. Paper presented at the 43th Annual Meeting of the Ophthalmological Society of the Republic of China, December 2002, Taipei, Taiwan, R.O.C.
  71. Zeie-Lun Huang, Shu-Wen Chang*. Recalcitrant, diffuse conjunctival papillomatosis. Poster presented at the 43th Annual Meeting of the Ophthalmological Society of the Republic of China, December 2002, Taipei, Taiwan, R.O.C.
  72. Hung-Chiao Chen, Shu-Wen Chang*. Treatment of bilateral papillomavirus associated conjunctival intraepithelial neoplasm with adjunctive interferonalpha-2b. Paper presented at the Second Global Chinese Ophthalmic Conference, June 2002 Taipei, Taiwan, R.O.C..
  73. Shu-Wen Chang*. Change of potassium current density in rabbit corneal epithelial cells during maturation. Paper presentation at the 7th International Ocular Surface Society Regional Meeting, Kyoto, Japan, October 2001.
  74. Chi-Chin Sun, Shu-Wen Chang*, Ray RF Tsai. Traumatic corneal perforation with epithelial ingrowth after laser in situ keratomileusis. Paper presented at the 40th Annual Meeting of the Ophthalmological Society of the Republic of China, December 1999, Taipei, Taiwan, R.O.C.
  75. Shu-Wen Chang*, Chau-ChungWu, Muh-Shy Chen, Por-Jau Huang,Yuan-The Lee. The Effect of Diet Therapy on the Hypercholestrolemia-induced Vascular Permeability Change in Rabbit Iris. Invest Ophthalmol Vis Sci 1999;40(suppl):S501.
  76. Shu-Wen Chang*, Chau-ChungWu, Muh-Shy Chen, Yuan-Teh Lee. Change of Blood Aqueous Barrier in Hyperlipidemic Patients. Invest Ophthalmol Vis Sci 1998;39(suppl):S600.
  77. Riad B. Shalash, Shu-Wen Chang*, Dimitri T. Azar. “Intraocular Pressure Reading Dudring Lamellar Refractive Surgery” paper presented at the 100th Annual Meeting of American Academy of Ophthalmology, Chicago, U.S.A., 1996.
  78. Shu-Wen Chang*, Farooq Ashraf, Robert A. Prendergast, Dimitri T. Azar. Corneal wound healing following perforated laser in situ keratomileusis. Invest Ophthalmol Vis Sci 1996;37(suppl):S569.
  79. Chau-ChungWu, Shu-Wen Chang*, Fung-Rong Hu, Ping-Kang Hou. Corneal epithelial recovery following photorefractive keratectomy. Invest Ophthalmol Vis Sci 1994;35(suppl):S1724.
  80. Wei-Jen Huang, Shu-Wen Chang*, Yau-Hong Wang, P.C. Yang, Ping-Kang Hou. Porcine keratocyte response following mechanical de-epithelialization in corneal preservation medium. Invest Ophthalmol Vis Sci 1994;35(suppl):S1859.
  81. Pi-Rong Lin, Fung-Rong Hu, Shu-Wen Chang*, June-Chiang Lieu. Topographic changes of corneas after lid speculum application in high myopes. Invest Ophthalmol Vis Sci 1992; 33(suppl):994.
  82. "Corneal epithelial barrier function following penetrating keratoplasty," paper presented at the 33th Annual Meeting of the Ophthalmological Society of the Republic of China, November 1992, Taipei, Taiwan, R.O.C.
  83. "Effects of refractive errors on corneal endothelium," paper presented at the 33th Annual Meeting of the Ophthalmological Society of the Republic of China, November 1992, Taipei, Taiwan, R.O.C.
  84. "Corneal epithelial permeability in Diabetic Patients," paper presented at the 33th Annual Meeting of the Ophthalmological Society of the Republic of China, November 1992, Taipei, Taiwan, R.O.C.
  85. "Acanthameba Keratitis Complicated from Penetrating Keratoplasty and Therapeutic Contact LensWearing -- A Case Report" paper presented at the 33th Annual Meeting of the Ophthalmological Society of the Republic of China, November 1992, Taipei, Taiwan, R.O.C.
  86. "Acute Calcareous Corneal Degeneration --- A Case Report" paper presented at the 33th Annual Meeting of the Ophthalmological Society of the Republic of China, November 1992, Taipei, Taiwan, R.O.C.
  87. "Topographic changes of corneas after lid speculum application in high myopes," paper presented at the ARVO meeting, May 1992, Sarasota, Fluorida, U.S.A..
  88. "Effects of Contact Lens on Corneal Endothelium," paper presented at the 30th Regional Meeting or the Ophthalmological Society of the Republic of China, May 1991, Kao-Shung, Taiwan, R.O.C.
  89. "Prevention of Intraocular Pressure Elevation Following Laser Iridotomy by Acetazolamide, Carteolol, and Apraclonidine," paper presented at the 26th Regional Meeting of the Ophthalmological Society of the Republic of China, May 1990, Taitung, Taiwan, R.O.C.
  90. "Endothelial Permeability in Diabetic Patients by Fluorophotometry," paper presented at the 30th Annual Meeting of the Ophthalmological Society of the Republic of China, November 1989, Taipei, Taiwan, R.O.C.

C. Book Chapters

  1. Shu-Wen Chang, Dimitri T. Azar. Section 3: Refractive Surgery. Automated and manual lamellar surgical procedures and epikeratoplasty. pp 164-172. In: Yanoff M, Duker J (eds) Ophthalmology 2nd edition, Mosby Inernational, London, England, 2003.
  2. Shu-Wen Chang, Dimitri T. Azar. Section 3: Refractive Surgery. Larmellar Refractive Procedures. In: Yanoff M, Duker J (eds) Ophthalmology, Mosby Inernational, London, England, 1998. Section 3: 5.1-5.10.
  3. Shu-Wen Chang, Suhas W. Tuli, Dimitri T. Azar. Corneal Dystrophies.In: Elias I. Traboulsi (ed) Genetic Diseases of the Eye. A textbook and Atlas. New York: Oxford University Press; 1998: p.217-266.
  4. Azar DT, Talamo JH, Helena MC, Stark WJ, Chang SW, Jain S. PTK: Indications, surgical techniques, postoperative care, and complications management. In: Talamo JH, Krueger RR, editors. The excimer manual: a clinician's guide to excimer laser surgery. Boston: Little, Brown, and Company; 1997. pp. 173-202.
  5. Shu-Wen Chang, Ruiz, Gomez. Lamellar Refractive Surgery -- Instrumentation. In: Dimitri T. Azar (ed) Corneal Surgery. CT, 1997. pp. 239-251.
  6. SuhasW. Tuli, Shu-Wen Chang, Dimitri T. Azar. Anterior corneal dystrophies: clinical features. In: Azar DT, Steinert RF, Stark WJ, editors. Excimer laser phototherapeutic keratectomy: Management of Scars, Dystrophies, and PRK Complications. Baltimore:Williams &Wilkins; 1997. pp. 73-98.
  7. Shu-Wen Chang, Suhas W. Tuli, Dimitri T. Azar. Photorefractive Keratectomy After Other Corneal Surgical Procedures. In: Talamo JH, Krueger RR (editors). The excimer manual: a clinician's guide to excimer laser surgery. Boston: Little, Brown, and Company; 1997. pp.108-120.

 

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