心血管核心專業創新研究團隊
Cardiovascular Research Team
研究內容
研究主題I
本團隊在過去的研究中已針對冠狀動脈繞道手術病患不同之靜脈摘取方式,比較內皮細胞的特定分子在蛋白質與RNA不同層次的變化與差異;亦針對疼痛及發炎反應設計一系列的實驗模式,以不同濃度、輸注速率、時間等變因比較局部輸注麻醉劑之效果。未來的研究方向將承襲過去的實驗模式,以心血管手術延伸出的臨床研究為主軸,包含冠狀動脈繞道手術、瓣膜手術、體外循環、疼痛控制、發炎反應等,利用基礎分生實驗的技術進行更深入的探討。
研究主題II
本實驗室以分離純化的神經末梢(突觸小體)模式,探討藥物對興奮性神經傳導物質麩胺酸釋放的影響,以此探討藥物是否具有神經保護的作用,其中不乏已在臨床上用於神經保護的藥物,而本實驗室所研究的藥物也從一開始的麻醉藥物包括propofol、dexmedetomidine及lidocaine,更擴展到其他有潛能的神經保護藥物如COX-2抑制劑、memantine等藥物,本著三段五級預防的精神,為了讓神經保護不是僅限於民眾就醫時才採取,我們也將中草藥納入我們的研究,讓民眾可以更及早的採取預防性的神經保護措施,在我們的研究中如丹蔘、木犀草素,去氫延胡索鹼及高車前素等都有不錯的神經保護效果。
研究主題III
癲癇是一種常見的慢性腦部疾病,目前使用的抗癲癇藥物伴隨很多副作用,甚至有近30%的病患對這些藥物治療沒有反應。因此,尋找及開發安全及有效的新藥物是必需的。本實驗室以興奮性神經毒性之動物模型,對大鼠投予紅藻氨酸(kainic acid,KA),KA是麩胺酸的類似物,它會促使大腦釋放大量的麩胺酸及造成麩胺酸受體的過度活化,進而引起大鼠的癲癇發作。中草藥具有潛在的藥理作用及較低的毒性,因此逐漸在全世界的醫療中受到重視。近年來,已有許多研究顯示植物衍生的產物在中樞神經系統具有治療的潛力。因此,我們利用KA誘發大鼠癲癇模式,從天然物發展出安全及有效的癲癇治療藥物,或許可以提供我們一個不同於西藥的選擇。
團隊成員
團隊主持人 邱冠明 院長
主治醫師 林子玊 副院長
研究員 李明怡 博士
合作單位
輔仁大學
論文發表
邱冠明 院長
Lu, C.W.; Lin, C.J.; Hsieh, P.W.; Chiu, K.M.; Lee, M.Y.; Lin, T.Y.; Wang, S.J. An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats. Int J Mol Sci 2022, 23, doi:10.3390/ijms23052641. Lin, T.-Y.; Chen, I.-Y.; Lee, M.-Y.; Lu, C.-W.; Chiu, K.M.; Wang, S.-J. Inhibition of Glutamate Release from Rat Cortical Nerve Terminals by Dehydrocorydaline, an Alkaloid from Corydalis yanhusuo. Molecules 2022, 27, 960. Huang, J.H.; Chang, H.T.; Liao, C.H.; Chiu, K.M. Rapid response of a medical center upon the surge of COVID-19 epidemic in Taiwan. J Microbiol Immunol Infect 2022, 55, 1-5, doi:10.1016/j.jmii.2021.11.003. Lu, C.W.; Lin, T.Y.; Pan, T.L.; Wang, P.W.; Chiu, K.M.; Lee, M.Y.; Wang, S.J. Asiatic Acid Prevents Cognitive Deficits by Inhibiting Calpain Activation and Preserving Synaptic and Mitochondrial Function in Rats with Kainic Acid-Induced Seizure. Biomedicines 2021, 9, doi:10.3390/biomedicines9030284. Lu, C.W.; Lin, T.Y.; Huang, S.K.; Chiu, K.M.; Lee, M.Y.; Huang, J.H.; Wang, S.J. Inhibition of glutamatergic transmission and neuronal excitability by oxycodone in the rat hippocampal CA3 neurons. Can J Physiol Pharmacol 2021, 99, 737-743, doi:10.1139/cjpp-2020-0469. Lu, C.W.; Huang, Y.C.; Chiu, K.M.; Lee, M.Y.; Lin, T.Y.; Wang, S.J. Enmein Decreases Synaptic Glutamate Release and Protects against Kainic Acid-Induced Brain Injury in Rats. Int J Mol Sci 2021, 22, doi:10.3390/ijms222312966. Lin, T.Y.; Lu, C.W.; Hsieh, P.W.; Chiu, K.M.; Lee, M.Y.; Wang, S.J. Natural Product Isoliquiritigenin Activates GABA(B) Receptors to Decrease Voltage-Gate Ca(2+) Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals. Biomolecules 2021, 11, doi:10.3390/biom11101537. Lim, K.X.; Chen, Y.T.; Chiu, K.M.; Hung, F.M. Rush Hour:Transform a modern hotel into cloud-based virtual ward care center within 80 hours under COVID-19 pandemic.Far eastern MemorialHospital's experience. J Formos Med Assoc 2021, 10.1016/j.jfma.2021.10.023, doi:10.1016/j.jfma.2021.10.023. Huang, Y.F.; Liu, S.P.; Muo, C.H.; Chen, H.J.; Liao, Y.F.; Chiu, K.M.; Chen, C.C.; Tsai, C.H.; Hong, H.H.; Chang, C.T. The impact of timing and modalities of dental prophylaxis on the risk of 5-fluorouracil-related oral mucositis in patients with head and neck cancer: a nationwide population-based cohort study. Support Care Cancer 2021, 29, 3163-3171, doi:10.1007/s00520-020-05825-y. Huang, Y.F.; Chang, C.T.; Muo, C.H.; Chiu, K.M.; Tsai, C.H.; Liu, S.P. Bidirectional relationship between temporomandibular disorder and ankylosing spondylitis: a population-based cohort study. Clin Oral Investig 2021, 25, 6377-6384, doi:10.1007/s00784-021-03938-0. Huang, J.H.; Chang, H.T.; Liao, C.H.; Chiu, K.M. Rapid response of a medical center upon the surge of COVID-19 epidemic in Taiwan. J Microbiol Immunol Infect 2021, 10.1016/j.jmii.2021.11.003, doi:10.1016/j.jmii.2021.11.003. Chung, C.S.; Tsai, I.F.; Lee, I.H.; Tsai, P.C.; Wu, M.Y.; Huang, Y.C.; Ma, J.Y.; Tseng, P.C.; Chiu, K.M.; Liao, C.H. Preventive strategy of gastrointestinal endoscopy unit against COVID-19: A tertiary center experience in Taiwan. J Microbiol Immunol Infect 2021, 54, 1003-1005, doi:10.1016/j.jmii.2021.04.003. Chiu, K.M.; Lin, T.Y.; Lee, M.Y.; Lu, C.W.; Wang, M.J.; Wang, S.J. Typhaneoside Suppresses Glutamate Release Through Inhibition of Voltage-Dependent Calcium Entry in Rat Cerebrocortical Nerve Terminals. Chem Res Toxicol 2021, 34, 1286-1295, doi:10.1021/acs.chemrestox.0c00446. Chiu, K.M.; Hung, Y.L.; Wang, S.J.; Tsai, Y.J.; Wu, N.L.; Liang, C.W.; Chang, D.C.; Hung, C.F. Anti-Allergic and Anti-Inflammatory Effects of Neferine on RBL-2H3 Cells. Int J Mol Sci 2021, 22, doi:10.3390/ijms222010994. Wang, K.L.; Kao, Y.T.; Chang, W.T.; Chang, H.Y.; Huang, W.C.; Hsu, P.C.; Hsu, C.H.; Huang, C.L.; Hsieh, L.C.; Wang, C.Y., et al. Management of Venous Thromboembolisms: Part II. The Consensus for Pulmonary Embolism and Updates. Acta Cardiol Sin 2020, 36, 562-582, doi:10.6515/acs.202011_36(6).20200917a. Tseng, P.Y.; Chen, Y.T.; Wang, C.H.; Chiu, K.M.; Peng, Y.S.; Hsu, S.P.; Chen, K.L.; Yang, C.Y.; Lee, O.K. Prediction of the development of acute kidney injury following cardiac surgery by machine learning. Crit Care 2020, 24, 478, doi:10.1186/s13054-020-03179-9. Lu, C.W.; Lin, T.Y.; Chiu, K.M.; Lee, M.Y.; Huang, J.H.; Wang, S.J. Silymarin Inhibits Glutamate Release and Prevents against Kainic Acid-Induced Excitotoxic Injury in Rats. Biomedicines 2020, 8, doi:10.3390/biomedicines8110486. Ko, K.Y.; Wang, S.Y.; Yen, R.F.; Shiau, Y.C.; Hsu, J.C.; Tsai, H.Y.; Lee, C.L.; Chiu, K.M.; Wu, Y.W. Clinical significance of quantitative assessment of glucose utilization in patients with ischemic cardiomyopathy. J Nucl Cardiol 2020, 27, 269-279, doi:10.1007/s12350-018-1395-4. Cheng, L.Y.; Wang, Y.C.; Chen, M.H.; Tung, F.I.; Chiu, K.M.; Liu, T.Y. An Engineered Gene Nanovehicle Developed for Smart Gene Therapy to Selectively Inhibit Smooth Muscle Cells: An In Vitro Study. Int J Mol Sci 2020, 21, doi:10.3390/ijms21041530. Tsai, S.Y.; Wu, Y.W.; Wang, S.Y.; Shiau, Y.C.; Chiu, K.M.; Tsai, H.Y.; Lee, C.L.; Hsu, J.C.; Tu, C.M.; Lin, H.H., et al. Clinical significance of quantitative assessment of right ventricular glucose metabolism in patients with heart failure with reduced ejection fraction. Eur J Nucl Med Mol Imaging 2019, 46, 2601-2609, doi:10.1007/s00259-019-04471-9. Guo, M.H.; Wells, G.A.; Glineur, D.; Fortier, J.; Davierwala, P.M.; Kikuchi, K.; Lemma, M.G.; Mishra, Y.K.; McGinn, J.; Ramchandani, M., et al. Minimally Invasive coronary surgery compared to STernotomy coronary artery bypass grafting: The MIST trial. Contemp Clin Trials 2019, 78, 140-145, doi:10.1016/j.cct.2019.01.006. De Caterina, R.; Agnelli, G.; Laeis, P.; Unverdorben, M.; Rauer, H.; Wang, C.C.; Nakamura, M.; Chiu, K.M.; Reimitz, P.E.; Koretsune, Y., et al. The global Edoxaban Treatment in routine cliNical prActice (ETNA) noninterventional study program: rationale and design. Clin Cardiol 2019, 42, 1147-1154, doi:10.1002/clc.23279. Chiu, K.M.; Lin, T.Y.; Lee, M.Y.; Lu, C.W.; Wang, M.J.; Wang, S.J. Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling. Neurochem Int 2019, 129, 104493, doi:10.1016/j.neuint.2019.104493. Huang, C.C.; Hsu, J.C.; Wu, Y.W.; Ke, S.R.; Huang, J.H.; Chiu, K.M.; Liao, P.C. Implementation of extracorporeal membrane oxygenation before primary percutaneous coronary intervention may improve the survival of patients with ST-segment elevation myocardial infarction and refractory cardiogenic shock. Int J Cardiol 2018, 269, 45-50, doi:10.1016/j.ijcard.2018.07.023. Hsu, H.L.; Chen, J.S.; Chiu, K.M. Modification of Thoracic Endografts to Treat Iatrogenic Type A Aortic Dissection: A Case Report. J Vasc Interv Radiol 2018, 29, 740-742, doi:10.1016/j.jvir.2017.09.001. Chiu, K.M.; Lin, T.Y.; Lee, M.Y.; Lu, C.W.; Wang, M.J.; Wang, S.J. Ropivacaine Protects against Memory Impairment and Hippocampal Damage in a Rat Neurodegeneration Model. Pharmacology 2018, 102, 307-315, doi:10.1159/000493145. Wang, K.L.; Chu, P.H.; Lee, C.H.; Pai, P.Y.; Lin, P.Y.; Shyu, K.G.; Chang, W.T.; Chiu, K.M.; Huang, C.L.; Lee, C.Y., et al. Management of Venous Thromboembolisms: Part I. The Consensus for Deep Vein Thrombosis. Acta Cardiol Sin 2016, 32, 1-22, doi:10.6515/acs20151228a. Chiu, K.M.; Lu, C.W.; Lee, M.Y.; Wang, M.J.; Lin, T.Y.; Wang, S.J. Neuroprotective and anti-inflammatory effects of lidocaine in kainic acid-injected rats. Neuroreport 2016, 27, 501-507, doi:10.1097/wnr.0000000000000570. Kuo, Y.T.; Chiu, K.M.; Tsang, Y.M.; Chiu, C.M.; Chien, M.Y. Influence of Chronic Kidney Disease on Physical Function and Quality of Life in Patients after Coronary Artery Bypass Grafting. Cardiorenal Med 2015, 5, 237-245, doi:10.1159/000433447. Chiu, K.M.; Wu, C.C.; Wang, M.J.; Lee, M.Y.; Wang, S.J. Protective effects of bupivacaine against kainic acid-induced seizure and neuronal cell death in the rat hippocampus. Biol Pharm Bull 2015, 38, 522-530, doi:10.1248/bpb.b14-00633. Chiu, K.M.; Lin, T.Y.; Chen, J.S.; Huang, J.H.; Chen, R.J.; Chu, S.H. Intraoperative Measurement of Fractional Flow Reserve in Off-Pump Coronary Artery Bypass: A Pilot Study. Thorac Cardiovasc Surg 2015, 63, 288-291, doi:10.1055/s-0034-1383815. Lu, C.W.; Lin, T.Y.; Shieh, J.S.; Wang, M.J.; Chiu, K.M. Antimicrobial effect of continuous lidocaine infusion in a Staphylococcus aureus-induced wound infection in a mouse model. Ann Plast Surg 2014, 73, 598-601, doi:10.1097/SAP.0b013e318276d8e7. Chiu, K.M.; Chen, R.J.; Lin, T.Y.; Chen, J.S.; Huang, J.H.; Huang, C.Y.; Chu, S.H. Right mini-parasternotomy may be a good minimally invasive alternative to full sternotomy for cardiac valve operations-a propensity-adjusted analysis. J Cardiovasc Surg (Torino) 2014. Chiu, K.M.; Chen, R.J. Videoscope-assisted cardiac surgery. J Thorac Dis 2014, 6, 22-30, doi:10.3978/j.issn.2072-1439.2014.01.04. Chen, J.S.; Huang, J.H.; Huang, C.Y.; Chiu, K.M. Delayed lung herniation after minimally invasive cardiac surgery. Eur J Cardiothorac Surg 2014, 45, e176, doi:10.1093/ejcts/ezu049. Zhang, D.; Chiu, K.M.; Wang, W.; Sun, D. Effects of conditioning with sevoflurane before reperfusion on hippocampal ischemic injury and insulin-like growth factor-1 expression in rats. Chin J Physiol 2013, 56, 236-242, doi:10.4077/cjp.2013.Bab117. Weng, M.T.; Wu, J.M.; Chiu, K.M. Gastropericardial fistula-caused pneumopericardium. Clin Gastroenterol Hepatol 2013, 11, e64-65, doi:10.1016/j.cgh.2012.12.021. Chiu, K.M.; Chen, R.J.; Lin, T.Y.; Chen, J.S.; Huang, J.H.; Chu, S.H. Cardioplegia delivery by transcutaneous pigtail catheter in minimally invasive mitral valve operations. Ann Thorac Surg 2013, 95, e77-78, doi:10.1016/j.athoracsur.2012.10.065. Chen, J.S.; Huang, J.H.; Chiu, K.M.; Chu, S.H. Pseudoaneurysm of the ascending aorta. Eur J Cardiothorac Surg 2013, 43, 1263, doi:10.1093/ejcts/ezs628. Tung, H.H.; Shen, S.F.; Shih, C.C.; Chiu, K.M.; Lee, J.Y.; Liu, C.Y. Effects of a preoperative individualized exercise program on selected recovery variables for cardiac surgery patients: A pilot study. J Saudi Heart Assoc 2012, 24, 153-161, doi:10.1016/j.jsha.2012.03.002. Cohen, A.; Chiu, K.M.; Park, K.; Jeyaindran, S.; Tambunan, K.L.; Ward, C.; Wong, R.; Yoon, S.S. Managing venous thromboembolism in Asia: winds of change in the era of new oral anticoagulants. Thromb Res 2012, 130, 291-301, doi:10.1016/j.thromres.2012.05.025. Wang, S.H.; Chiu, K.M.; Cheng, P.W. Bilateral carotid body paragangliomas. Cmaj 2011, 183, E606, doi:10.1503/cmaj.092114. Huang, C.Y.; Chiu, K.M.; Chung, S.D.; Keller, J.J.; Huang, C.C.; Lin, H.C. Increased risk of depressive disorder following the diagnosis of benign prostatic enlargement: one-year follow-up study. J Affect Disord 2011, 135, 395-399, doi:10.1016/j.jad.2011.07.001. Chung, S.D.; Kang, J.H.; Liao, C.H.; Chiu, K.M.; Lin, H.C. Increased risk for cancer following erectile dysfunction: a nationwide population-based follow-up study. J Sex Med 2011, 8, 1513-1520, doi:10.1111/j.1743-6109.2010.02076.x. Chiu, K.M.; Lin, T.Y.; Lu, C.W.; Wang, S.J. Inhibitory effect of glutamate release from rat cerebrocortical nerve terminals by α2 adrenoceptor agonist dexmedetomidine. Eur J Pharmacol 2011, 670, 137-147, doi:10.1016/j.ejphar.2011.08.012. Chen, J.S.; Huang, J.H.; Chu, S.H.; Chiu, K.M. Left ventricular pseudoaneurysm after apicoaortic bypass. Eur J Cardiothorac Surg 2011, 40, e132, doi:10.1016/j.ejcts.2011.04.036. Lai, C.L.; Chiu, K.M.; Chu, S.H. The duet played by two donor hearts beating simultaneously in a patient. Circulation 2010, 121, 341-344, doi:10.1161/circulationaha.109.879817. Huang, J.H.; Chen, J.S.; Chu, S.H.; Chiu, K.M. Recurrent cervical carcinoma presenting as a primary aortoduodenal fistula. Ann Vasc Surg 2010, 24, 1133.e1135-1137, doi:10.1016/j.avsg.2009.12.017. Chen, J.S.; Chiu, K.M.; Chu, S.H.; Huang, J.H. Dislodged aortic mechanical prosthesis. Tex Heart Inst J 2010, 37, 373. Chen, J.S.; Chiu, K.M.; Chu, S.H.; Huang, J.H. Esophageal erosion after stent graft implantation for a Salmonella mycotic aneurysm. Ann Thorac Surg 2010, 90, 672, doi:10.1016/j.athoracsur.2009.09.085. Lin, T.Y.; Horng, F.M.; Chiu, K.M.; Chu, S.H.; Shieh, J.S. A simple modification of inflow cannula to reduce recirculation of venovenous extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg 2009, 138, 503-506, doi:10.1016/j.jtcvs.2008.02.095. Lin, T.Y.; Chiu, K.M.; Shieh, J.S.; Chu, S.H. Surgical treatment of left main coronary artery aneurysm: a case report. Circ J 2009, 73, 770-771, doi:10.1253/circj.cj-08-0114. Lin, T.Y.; Chen, Y.S.; Chiu, K.M.; Hsu, R.B.; Yu, H.Y.; Wang, M.J. Eight-year experience of intraoperative aortic dissection. Asian Cardiovasc Thorac Ann 2009, 17, 408-412, doi:10.1177/0218492309341784. Chen, Y.; Wu, J.M.; Lin, T.Y.; Wu, C.C.; Chiu, K.M.; Chang, B.F.; Tseng, S.H.; Chu, S.H. Tetrandrine ameliorated reperfusion injury of small bowel transplantation. J Pediatr Surg 2009, 44, 2145-2152, doi:10.1016/j.jpedsurg.2009.06.002. Lin, T.Y.; Chiu, K.M.; Shieh, J.S.; Chu, S.H. Emergency redo mitral valve replacement in a pregnant woman at third trimester: case report and literature review. Circ J 2008, 72, 1715-1717, doi:10.1253/circj.cj-07-0775. Lai, H.Y.; Chen, J.H.; Chiu, K.M.; Wang, K.L.; Cheung, W.K.; Li, A.H.; Chu, S.H. CT of two hearts beating in one chest. AJR Am J Roentgenol 2008, 191, 1711-1716, doi:10.2214/ajr.07.3813. Chiu, K.M.; Wu, C.C.; Wang, M.J.; Lu, C.W.; Shieh, J.S.; Lin, T.Y.; Chu, S.H. Local infusion of bupivacaine combined with intravenous patient-controlled analgesia provides better pain relief than intravenous patient-controlled analgesia alone in patients undergoing minimally invasive cardiac surgery. J Thorac Cardiovasc Surg 2008, 135, 1348-1352, doi:10.1016/j.jtcvs.2008.01.020. Chiu, K.M.; Lin, T.Y.; Chu, S.H.; Chen, J.S. Total laparoscopic repair for abdominal aortic aneurysm. J Formos Med Assoc 2008, 107, 667-672, doi:10.1016/s0929-6646(08)60186-2. Chiu, K.M.; Lin, T.Y.; Chu, S.H. Images in cardiovascular medicine. Huge femoral artery pseudoaneurysm. Circulation 2008, 117, 1100, doi:10.1161/circulationaha.107.739359. Chiu, K.M.; Lin, T.Y.; Chen, J.S.; Chu, S.H. Percutaneous cardioplegia delivery using the miniport in minimally invasive mitral valve surgery. Interact Cardiovasc Thorac Surg 2008, 7, 342-343, doi:10.1510/icvts.2007.164194. Chiu, K.M.; Chu, S.H.; Lin, T.Y. Left atrial isomerism with right pulmonary artery thrombosis. Eur J Cardiothorac Surg 2008, 33, 112, doi:10.1016/j.ejcts.2007.09.027. Lin, T.Y.; Chiu, K.M.; Lu, C.W.; Jean, W.H.; Wang, M.J.; Chu, S.H. Immediate extubation in the operating room after cardiac operations with thoracotomy and sternotomy. Acta Anaesthesiol Taiwan 2007, 45, 3-8. Chuang, W.P.; Chiu, K.M. Pigtail slip-knot catches the heart. Catheter Cardiovasc Interv 2007, 70, 824-825, doi:10.1002/ccd.21228. Chu, S.H.; Chiu, K.M.; Lin, T.Y.; Chu, T.W.; Yeih, D.F.; Li, A.H. Two donor hearts beat in one chest. Tex Heart Inst J 2007, 34, 230-232. Chiu, K.M.; Li, S.J.; Lin, T.Y.; Chan, C.Y.; Chu, S.H. Innominate artery cannulation for aortic surgery. Asian Cardiovasc Thorac Ann 2007, 15, 348-350, doi:10.1177/021849230701500419. Chiu, K.M.; Chu, S.H.; Li, S.J. Kommerell's aneurysm. Eur Heart J 2007, 28, 820, doi:10.1093/eurheartj/ehl301. Chiu, K.M.; Chu, S.H.; Chen, J.S.; Li, S.J.; Chan, C.Y.; Chen, K.S. Spiral saphenous vein graft for portal vein reconstruction in pancreatic cancer surgery. Vasc Endovascular Surg 2007, 41, 149-152, doi:10.1177/1538574406297259. Chiu, K.M.; Chu, S.H.; Chan, C.Y. Dislodged caval stent in right pulmonary artery. Catheter Cardiovasc Interv 2007, 70, 799-800, doi:10.1002/ccd.21251. Chiu, K.M.; Chan, H.L.; Chu, S.H.; Lin, T.Y. Carvedilol can restore the multifractal properties of heart beat dynamics in patients with advanced congestive heart failure. Auton Neurosci 2007, 132, 76-80, doi:10.1016/j.autneu.2006.10.008. Chiu, K.M.; Lin, T.Y.; Wang, M.J.; Chu, S.H. Reduction of carbon dioxide embolism for endoscopic saphenous vein harvesting. Ann Thorac Surg 2006, 81, 1697-1699, doi:10.1016/j.athoracsur.2005.12.040. Chiu, K.M.; Lin, T.Y.; Wang, M.J. Huge right coronary artery aneurysm in a young adult. Eur Heart J 2006, 27, 2195, doi:10.1093/eurheartj/ehi789. Chiu, K.M.; Lin, T.Y.; Li, S.J.; Chen, J.S.; Chu, S.H. Less invasive mitral valve surgery via right minithoracotomy. J Formos Med Assoc 2006, 105, 715-721, doi:10.1016/s0929-6646(09)60199-6. Chiu, K.M.; Lin, T.Y.; Li, S.J.; Chan, C.Y.; Chu, S.H. Surgical resection of primary cardiac lymphoma. Clin Lymphoma Myeloma 2006, 6, 420-421, doi:10.3816/CLM.2006.n.023. Chiu, K.M.; Lin, T.Y.; Chu, S.H.; Lu, C.W. Managing sternal osteomyelitis with antibiotic bead implantation. Asian Cardiovasc Thorac Ann 2006, 14, e41-42, doi:10.1177/021849230601400233. Chiu, K.M.; Lin, T.Y.; Chen, J.S.; Li, S.J.; Chan, C.Y.; Chu, S.H. Images in cardiovascular medicine. Left ventricle apical conduit to bilateral subclavian artery in a patient with porcelain aorta and aortic stenosis. Circulation 2006, 113, e388-389, doi:10.1161/circulationaha.105.548065. Chiu, K.M.; Li, S.J.; Chen, J.S.; Lin, T.Y.; Chan, C.Y.; Chu, S.H. Endoscopic radial artery harvest for coronary artery bypass surgery. J Formos Med Assoc 2006, 105, 384-389, doi:10.1016/s0929-6646(09)60134-0. Lin, T.Y.; Chen, Y.; Chiu, K.M.; Lu, C.W.; Jean, W.H.; Horng, F.M.; Chu, S.H. Cell saver does not increase pro-inflammatory cytokine levels and expression of adhesive molecules in the salvaged blood of patients undergoing off-pump coronary artery bypass surgery. Acta Anaesthesiol Taiwan 2005, 43, 211-215. Chiu, K.M.; Lin, T.Y.; Chen, J.S.; Li, S.J.; Chu, S.H. Tricuspid valve replacement with a cryopreserved pulmonary homograft. J Thorac Cardiovasc Surg 2005, 130, e1-2, doi:10.1016/j.jtcvs.2005.07.022. Chiu, K.M.; Li, S.J.; Hung, F.M.; Chu, S.H.; Tzu, Y. Right heart bypass for acute traumatic respiratory distress syndrome. Asaio j 2005, 51, 826-828, doi:10.1097/01.mat.0000183688.96065.0d. Chiu, K.M.; Chen, J.S.; Yeh, S.J.; Lin, T.Y.; Ma, J.Y.; Li, S.J.; Chu, S.H. Hybrid angioplasty for left pulmonary artery stenosis after total correction of tetralogy of Fallot: report of one case. Acta Paediatr Taiwan 2005, 46, 174-177. Chiu, K.M.; Yu, H.Y.; Huang, S.C.; Chiu, K.M.; Lin, T.Y.; Lai, L.P.; Lin, F.Y.; Wang, S.S.; Chu, S.H.; Ko, W.J. Experience and result of extracorporeal membrane oxygenation in treating fulminant myocarditis with shock: what mechanical support should be considered first? J Heart Lung Transplant 2005, 24, 81-87, doi:10.1016/j.healun.2003.09.038. Lin, Y.C.; Ma, J.Y.; Yeh, S.J.; Chiu, K.M.; Chu, S.H. Use of extracorporeal membrane oxygenation to rescue a newborn with early-onset group B streptococcal sepsis and cardiopulmonary failure. J Formos Med Assoc 2004, 103, 67-70. Lin, T.Y.; Chiu, K.M.; Chien, C.Y.; Wang, M.J.; Chu, S.H. Case 1. Right ventricular outflow obstruction caused by metastatic hepatocellular carcinoma. J Clin Oncol 2004, 22, 1152-1153, doi:10.1200/jco.2004.04.151. Li, A.H.; Chan, L.; Chu, Y.T.; Chiu, K.M.; Chu, S.H. Weight-adjusted and activated clotting time-guided heparinization might reduce the postprocedural hemorrhage in percutaneous transluminal angioplasty for acute middle cerebral artery occlusion. Stroke 2004, 35, e77-78; author reply e77-78, doi:10.1161/01.Str.0000121162.48987.Db. Chiu, K.M.; Lin, T.Y.; Huang, P.H.; Chu, S.H. Hand-assisted laparoscopic surgery for abdominal aortic aneurysm. J Formos Med Assoc 2004, 103, 724-726. Lin, T.Y.; Chiu, K.M.; Wang, M.J.; Chu, S.H. Carbon dioxide embolism during endoscopic saphenous vein harvesting in coronary artery bypass surgery. J Thorac Cardiovasc Surg 2003, 126, 2011-2015, doi:10.1016/s0022-5223(03)01323-0.林子玊 副院長
Lu, C.W.; Lin, C.J.; Hsieh, P.W.; Chiu, K.M.; Lee, M.Y.; Lin, T.Y.; Wang, S.J. An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats. Int J Mol Sci 2022, 23, doi:10.3390/ijms23052641. Lin, T.Y.; Chen, I.-Y.; Lee, M.-Y.; Lu, C.-W.; Chiu, K.-M.; Wang, S.-J. Inhibition of Glutamate Release from Rat Cortical Nerve Terminals by Dehydrocorydaline, an Alkaloid from Corydalis yanhusuo. Molecules 2022, 27, 960. Wei, T.-J.; Wang, C.-H.; Chan, W.-S.; Huang, C.-H.; Lai, C.-H.; Wang, M.-J.; Chen, Y.-S.; Ince, C.; Lin, Lin, T.Y.; Yeh, Y.-C. Microcirculatory Response to Changes in Venoarterial Extracorporeal Membrane Oxygenation Pump Flow: A Prospective Observational Study. Frontiers in Medicine 2021, 8. Wang, S.J.; Lu, C.-W.; Lin, T.Y.; Pan, T.-L.; Wang, P.-W.; Chiu, K.-M.; Lee, M.-Y.; Wang, S.-J. Asiatic Acid Prevents Cognitive Deficits by Inhibiting Calpain Activation and Preserving Synaptic and Mitochondrial Function in Rats with Kainic Acid-Induced Seizure. Biomedicines 2021. Lu, C.W.; Lin, T.Y.; Huang, S.K.; Chiu, K.M.; Lee, M.Y.; Huang, J.H.; Wang, S.J. Inhibition of glutamatergic transmission and neuronal excitability by oxycodone in the rat hippocampal CA3 neurons. Can J Physiol Pharmacol 2021, 99, 737-743, doi:10.1139/cjpp-2020-0469. Lu, C.W.; Huang, Y.C.; Chiu, K.M.; Lee, M.Y.; Lin, T.Y.; Wang, S.J. Enmein Decreases Synaptic Glutamate Release and Protects against Kainic Acid-Induced Brain Injury in Rats. Int J Mol Sci 2021, 22, doi:10.3390/ijms222312966. Lin, T.Y.; Lu, C.W.; Hsieh, P.W.; Chiu, K.M.; Lee, M.Y.; Wang, S.J. Natural Product Isoliquiritigenin Activates GABA(B) Receptors to Decrease Voltage-Gate Ca(2+) Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals. Biomolecules 2021, 11, doi:10.3390/biom11101537. Khoi, C.S.; Lin, Y.W.; Chen, J.H.; Liu, B.H.; Lin, T.Y.; Hung, K.Y.; Chiang, C.K. Selective Activation of Endoplasmic Reticulum Stress by Reactive-Oxygen-Species-Mediated Ochratoxin A-Induced Apoptosis in Tubular Epithelial Cells. Int J Mol Sci 2021, 22, doi:10.3390/ijms222010951. Khoi, C.S.; Chen, J.H.; Lin, T.Y.; Chiang, C.K.; Hung, K.Y. Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence. Int J Mol Sci 2021, 22, doi:10.3390/ijms222011237. Chiu, K.-M.; Lin, T.Y.; Lee, M.-Y.; Lu, C.-W.; Wang, M.-J.; Wang, S.-J. Typhaneoside Suppresses Glutamate Release Through Inhibition of Voltage-Dependent Calcium Entry in Rat Cerebrocortical Nerve Terminals. Chemical Research in Toxicology 2021, 34, 1286–1295-1286–1295. Chang, Y.-Y.; Lu, C.-W.; Jean, W.-H.; Shieh, J.-S.; Lin, T.Y. Phorbol myristate acetate induces differentiation of THP-1 cells in a nitric oxide-dependent manner. Nitric Oxide 2021, 109-110, 33–41-33–41. Wang, S.J.; Lu, C.-W.; Lin, T.Y.; Chiu, K.-M.; Lee, M.-Y.; Huang, J.-H.; Wang, S.-J. Silymarin Inhibits Glutamate Release and Prevents against Kainic Acid-Induced Excitotoxic Injury in Rats. Biomedicines 2020. Lu, C.W.; Lin, T.Y.; Wang, S.J. 11-Keto-\upbeta{}{-}{B}oswellic Acid Attenuates Glutamate Release and Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus. Planta Medica 2020, 86, 434–441-434–441. Lu, C.-W.; Lin, T.Y.; Huang, S.-K.; Chiu, K.-M.; Lee, M.-Y.; Huang, J.-H.; Wang, S.-J. Inhibition of glutamatergic transmission and neuronal excitability by oxycodone in the rat hippocampal CA3 neurons. Canadian Journal of Physiology and Pharmacology 2020, 1–7-1–7. Chang, Y.Y.; Jean, W.H.; Lu, C.W.; Shieh, J.S.; Chen, M.L.; Lin, T.Y. Nicardipine Inhibits Priming of the NLRP3 Inflammasome via Suppressing LPS-Induced TLR4 Expression. Inflammation 2020, 43, 1375-1386, doi:10.1007/s10753-020-01215-y. Lu, C.W.; Lin, T.Y.; Wang, S.J.; Huang, S.K. Asiatic acid, an active substance of Centella asiatica, presynaptically depresses glutamate release in the rat hippocampus. European Journal of Pharmacology 2019, 865, 172781-172781. Lu, C.-W.; Hung, C.-F.; Lin, T.Y.; Hsieh, T.Y.; Wang, S.J. Allicin Inhibits Glutamate Release from Rat Cerebral Cortex Nerve Terminals Through Suppressing Ca2$\mathplus$ Influx and Protein Kinase C Activity. Journal of Medicinal Food 2019, 22, 696–702-696–702. Huang, S.K.; Lin, T.Y.; Wang, S.-J. Tapentadol Suppresses Glutamatergic Transmission and Neuronal Firing in Rat Hippocampal CA3 Pyramidal Neurons. Pharmacology 2019, 105, 445–453-445–453. Chiu, K.-M.; Lin, T.Y.; Lee, M.-Y.; Lu, C.-W.; Wang, M.-J.; Wang, S.-J. Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling. Neurochemistry International 2019, 129, 104493-104493. Chang, Y.-Y.; Lin, T.Y.; Kao, M.-C.; Chen, T.-Y.; Cheng, C.-F.; Wong, C.-S.; Huang, C.-J. Magnesium sulfate inhibits binding of lipopolysaccharide to THP-1 cells by reducing expression of cluster of differentiation 14. Inflammopharmacology 2019, 27, 249–260-249–260. Lu, C.W.; Lin, T.Y.; Huang, S.K.; Wang, S.J. 5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2018, 86, 122–130-122–130. Lu, C.W.; Hsieh, H.L.; Lin, T.Y.; Hsieh, T.Y.; Huang, S.K.; Wang, S.J. Echinacoside, an Active Constituent of $\less$i$\greater$Cistanche Herba$\less$/i$\greater$, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/{GSK}3$\upbeta$ Pathway. Biological and Pharmaceutical Bulletin 2018, 41, 1685–1693-1685–1693. Lu, C.-W.; Hung, C.-F.; Jean, W.-H.; Lin, T.Y.; Huang, S.-K.; Wang, S.-J. Lycopene depresses glutamate release through inhibition of voltage-dependent Ca2$\mathplus$ entry and protein kinase C in rat cerebrocortical nerve terminals. Canadian Journal of Physiology and Pharmacology 2018, 96, 479–484-479–484. Lu, C.-W.; Huang, S.-K.; Lin, T.Y.; Wang, S.-J. Echinacoside, an active constituent of Herba Cistanche, suppresses epileptiform activity in hippocampal CA3 pyramidal neurons. The Korean Journal of Physiology & Pharmacology 2018, 22, 249-249. Chiu, K.-M.; Lin, T.Y.; Lee, M.-Y.; Lu, C.-W.; Wang, M.-J.; Wang, S.-J. Ropivacaine Protects against Memory Impairment and Hippocampal Damage in a Rat Neurodegeneration Model. Pharmacology 2018, 102, 307–315-307–315. Chang, Y.; Lu, C.W.; Chen, Y.J.; Lin, T.Y.; Huang, S.K.; Wang, S.J. Astaxanthin protects against kainic acid-induced seizures and pathological consequences. Neurochemistry International 2018, 116, 85–94-85–94. Yeh, Y.-C.; Yu, L.C.-H.; Wu, C.-Y.; Cheng, Y.-J.; Lee, C.-T.; Sun, W.-Z.; Tsai, J.-C.; Lin, T.Y. Effects of endotoxin absorber hemoperfusion on microcirculation in septic pigs. Journal of Surgical Research 2017, 211, 242–250-242–250. Lu, C.W.; Lin, T.Y.; Huang, S.K.; Wang, S.J. Inhibition of glutamate release by cilnidipine in rat cerebrocortical nerve terminals (synaptosomes). NeuroReport 2017, 28, 527–532-527–532. Lu, C.W.; Lin, T.Y.; Hsie, T.Y.; Huang, S.K.; Wang, S.J. Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats. Food & Function 2017, 8, 1859–1868-1859–1868. Lu, C.-W.; Lin, T.Y.; Chang, C.-Y.; Huang, S.-K.; Wang, S.-J. Ciproxifan, a histamine H3 receptor antagonist and inverse agonist, presynaptically inhibits glutamate release in rat hippocampus. Toxicology and Applied Pharmacology 2017, 319, 12–21-12–21. Wang, H.Y.; Lu, C.W.; Lin, T.Y.; Kuo, J.R.; Wang, S.J. WAY208466 inhibits glutamate release at hippocampal nerve terminals. European Journal of Pharmacology 2016, 781, 117–127-117–127. Lu, C.; Lin, T.; Huang, S.; Wang, S. Echinacoside Inhibits Glutamate Release by Suppressing Voltage-Dependent Ca2$\mathplus$ Entry and Protein Kinase C in Rat Cerebrocortical Nerve Terminals. International Journal of Molecular Sciences 2016, 17, 1006-1006. Lin, T.Y.; Lu, C.W.; Wang, S.J. Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats. NeuroToxicology 2016, 55, 48–57-48–57. Chiu, K.M.; Lu, C.W.; Lee, M.Y.; Wang, M.J.; Lin, T.Y.; Wang, S.J. Neuroprotective and anti-inflammatory effects of lidocaine in kainic acid-injected rats. NeuroReport 2016, 27, 501–507-501–507. Chang, Y.; Lu, C.W.; Lin, T.Y.; Huang, S.K.; Wang, S.J. Baicalein, a Constituent of Scutellaria baicalensis, Reduces Glutamate Release and Protects Neuronal Cell Against Kainic Acid-Induced Excitotoxicity in Rats. The American Journal of Chinese Medicine 2016, 44, 943–962-943–962. Chang, Y.; Lin, T.Y.; Lu, C.W.; Huang, S.K.; Wang, Y.C.; Wang, S.J. Xanthohumol-induced presynaptic reduction of glutamate release in the rat hippocampus. Food & Function 2016, 7, 212–226-212–226. Lin, T.Y.; Lu, C.W.; Wang, S.J.; Huang, S.K. Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats. European Journal of Pharmacology 2015, 755, 6–15-16–15. Lin, T.Y.; Lu, C.-W.; Wu, C.-C.; Huang, S.-K.; Wang, S.-J. Palmitoylethanolamide Inhibits Glutamate Release in Rat Cerebrocortical Nerve Terminals. International Journal of Molecular Sciences 2015, 16, 5555–5571-5555–5571. Khoi, C.S.; Wong, J.J.; Wang, H.C.; Lu, C.W.; Lin, T.Y. Age correlates with hypotension during propofol-based anesthesia for endoscopic retrograde cholangiopancreatography. Acta Anaesthesiol Taiwan 2015, 53, 131-134, doi:10.1016/j.aat.2015.10.002. Chang, C.Y.; Lin, T.Y.; Lu, C.W.; Wang, C.C.; Wang, Y.C.; Chou, S.S.P.; Wang, S.J. Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. European Journal of Pharmacology 2015, 762, 72–81-72–81. Chang, C.Y.; Lin, T.Y.; Lu, C.W.; Huang, S.K.; Wang, Y.C.; Chou, S.S.P.; Wang, S.J. Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats. NeuroToxicology 2015, 50, 157–169-157–169. Lu, C.-W.; Lin, T.Y.; Shieh, J.-S.; Wang, M.-J.; Chiu, K.-M. Antimicrobial Effect of Continuous Lidocaine Infusion in a Staphylococcus aureus-Induced Wound Infection in a Mouse Model. Annals of Plastic Surgery 2014, 73, 598–601-598–601. Lin, T.Y.; Lu, C.-W.; Wang, C.-C.; Huang, S.K.; Wang, S.-J. Cyclooxygenase 2 Inhibitor Celecoxib Inhibits Glutamate Release by Attenuating the PGE2/EP2 Pathway in Rat Cerebral Cortex Endings. Journal of Pharmacology and Experimental Therapeutics 2014, 351, 134–145-134–145. Lin, T.Y.; Huang, W.-J.; Wu, C.-C.; Lu, C.-W.; Wang, S.-J. Acacetin Inhibits Glutamate Release and Prevents Kainic Acid-Induced Neurotoxicity in Rats. PLoS ONE 2014, 9, e88644-e88644. Chiu, K.-M.; Lin, T.Y.; Chen, J.-S.; Huang, J.-H.; Chen, R.; Chu, S.-H. Intraoperative Measurement of Fractional Flow Reserve in Off-Pump Coronary Artery Bypass: A Pilot Study. The Thoracic and Cardiovascular Surgeon 2014, 63, 288–291-288–291. Lu, C.-W.; Lin, T.Y.; Wang, S.-J. Quercetin inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex. NeuroToxicology 2013, 39, 1–9-1–9. Lin, T.Y.; Lu, C.W.; Huang, S.-K.; Wang, S.-J. Ferulic Acid Suppresses Glutamate Release Through Inhibition of Voltage-Dependent Calcium Entry in Rat Cerebrocortical Nerve Terminals. Journal of Medicinal Food 2013, 16, 112–119-112–119. Lin, T.Y.; Lu, C.W.; Huang, S.-K.; Wang, S.-J. Tanshinone IIA, a constituent of Danshen, inhibits the release of glutamate in rat cerebrocortical nerve terminals. Journal of Ethnopharmacology 2013, 147, 488–496-488–496. Lin, T.Y.; Lin, Y.-W.; Lu, C.-W.; Huang, S.-K.; Wang, S.-J. Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex. PLoS ONE 2013, 8, e67215-e67215. Lin, T.Y.; Chung, C.-Y.; Lu, C.-W.; Huang, S.-K.; Shieh, J.-S.; Wang, S.-J. Local anesthetics inhibit glutamate release from rat cerebral cortex synaptosomes. Synapse 2013, 67, 568–579-568–579. Chiu, K.-M.; Chen, R.J.-c.; Lin, T.Y.; Chen, J.-S.; Huang, J.-H.; Chu, S.-H. Cardioplegia Delivery by Transcutaneous Pigtail Catheter in Minimally Invasive Mitral Valve Operations. The Annals of Thoracic Surgery 2013, 95, e77–e78-e77–e78. Yeh, Y.-C.; Sun, W.-Z.; Ko, W.-J.; Chan, W.-S.; Fan, S.-Z.; Tsai, J.-C.; Lin, T.Y. Dexmedetomidine Prevents Alterations of Intestinal Microcirculation That Are Induced by Surgical Stress and Pain in a Novel Rat Model. Anesthesia & Analgesia 2012, 115, 46–53-46–53. Lu, C.W.; Lin, T.Y.; Wang, C.C.; Wang, S.J. σ-1 Receptor agonist SKF10047 inhibits glutamate release in rat cerebral cortex nerve endings. J Pharmacol Exp Ther 2012, 341, 532-542, doi:10.1124/jpet.111.191189. Lin, T.Y.; Lu, C.W.; Huang, W.J.; Wang, S.J. Involvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endings. Synapse 2012, 66, 232-239, doi:10.1002/syn.21505. Lin, T.Y.; Lu, C.W.; Huang, S.K.; Wang, S.J. Curcumin Inhibits Glutamate Release from Rat Prefrontal Nerve Endings by Affecting Vesicle Mobilization. International Journal of Molecular Sciences 2012, 13, 9097–9109-9097–9109. Lin, T.Y.; Lu, C.-W.; Wang, C.-C.; Lu, J.-F.; Wang, S.-J. Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. Toxicology and Applied Pharmacology 2012, 263, 233–243-233–243. Lin, C.T.; Tsai, Y.J.; Wang, H.Y.; Chen, S.H.; Lin, T.Y.; Lue, J.H. Pre-emptive treatment of lidocaine attenuates neuropathic pain and reduces pain-related biochemical markers in the rat cuneate nucleus in median nerve chronic constriction injury model. Anesthesiol Res Pract 2012, 2012, 921405, doi:10.1155/2012/921405. Lin, T.Y.; Lu, C.W.; Wang, C.C.; Wang, Y.C.; Wang, S.J. Curcumin inhibits glutamate release in nerve terminals from rat prefrontal cortex: possible relevance to its antidepressant mechanism. Prog Neuropsychopharmacol Biol Psychiatry 2011, 35, 1785-1793, doi:10.1016/j.pnpbp.2011.06.012. Lin, T.Y.; Lu, C.W.; Chang, C.C.; Huang, S.K.; Wang, S.J. Luteolin Inhibits the Release of Glutamate in Rat Cerebrocortical Nerve Terminals. Journal of Agricultural and Food Chemistry 2011, 59, 8458–8466-8458–8466. Lin, T.Y.; Lu, C.-W.; Huang, S.-K.; Chou, S.-S.P.; Kuo, Y.-C.; Chou, S.-H.; Tzeng, W.-F.; Leu, C.-Y.; Huang, R.-F.S.; Liew, Y.-F., et al. {HTDP}-2, a New Synthetic Compound, Inhibits Glutamate Release through Reduction of Voltage-Dependent Ca2$\mathplus$ Influx in Rat Cerebral Cortex Nerve Terminals. Pharmacology 2011, 88, 26–32-26–32. Chiu, K.M.; Lin, T.Y.; Lu, C.W.; Wang, S.J. Inhibitory effect of glutamate release from rat cerebrocortical nerve terminals by α2 adrenoceptor agonist dexmedetomidine. Eur J Pharmacol 2011, 670, 137-147, doi:10.1016/j.ejphar.2011.08.012. Wu, J.M.; Chen, Y.; Chen, J.C.; Lin, T.Y.; Tseng, S.H. Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice. Cancer Lett 2010, 287, 187-195, doi:10.1016/j.canlet.2009.06.009. Lu, C.-W.; Lin, T.Y.; Wang, S.-J. Memantine depresses glutamate release through inhibition of voltage-dependent Ca2$\mathplus$ entry and protein kinase C in rat cerebral cortex nerve terminals: An {NMDA} receptor-independent mechanism. Neurochemistry International 2010, 57, 168–176-168–176. Lu, C.-W.; Jean, W.-H.; Wu, C.-C.; Shieh, J.-S.; Lin, T.Y. Antiemetic efficacy of metoclopramide and diphenhydramine added to patient-controlled morphine analgesia: a randomised controlled trial. European Journal of Anaesthesiology 2010, 27, 1052–1057-1052–1057. Lin, T.Y.; Lu, C.W.; Wang, S.J. Astaxanthin Inhibits Glutamate Release in Rat Cerebral Cortex Nerve Terminals via Suppression of Voltage-Dependent Ca2$\mathplus$ Entry and Mitogen-Activated Protein Kinase Signaling Pathway. Journal of Agricultural and Food Chemistry 2010, 58, 8271–8278-8271–8278. Lin, T.Y.; Lu, C.W.; Huang, W.J.; Wang, S.J. Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings. Synapse 2010, 64, 390-396, doi:10.1002/syn.20738. Lin, T.Y.; Chiu, K.M.; Shieh, J.S.; Chu, S.H. Surgical treatment of left main coronary artery aneurysm: a case report. Circ J 2009, 73, 770-771, doi:10.1253/circj.cj-08-0114. Lin, T.Y.; Tseng, S.-H.; Li, S.-J.; Chen, J.-C.; Shieh, J.-S.; Chen, Y. Tetrandrine Increased the Survival Rate of Mice With Lipopolysaccharide-Induced Endotoxemia. Journal of Trauma: Injury, Infection & Critical Care 2009, 66, 411–417-411–417. Lin, T.Y..; Lu, C.-W.; Wang, S.-J. Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochemistry International 2009, 54, 526–534-526–534. Lin, T.Y.; Lu, C.-W.; Tien, L.-T.; Chuang, S.-H.; Wang, Y.-R.; Chang, W.-H.; Wang, S.-J. Fangchinoline inhibits glutamate release from rat cerebral cortex nerve terminals (synaptosomes). Neurochemistry International 2009, 54, 506–512-506–512. Lin, T.Y.; Horng, F.-M.; Chiu, K.-M.; Chu, S.-H.; Shieh, J.-S. A simple modification of inflow cannula to reduce recirculation of venovenous extracorporeal membrane oxygenation. The Journal of Thoracic and Cardiovascular Surgery 2009, 138, 503–506-503–506. Lin, T.Y.; Chen, Y.-S.; Chiu, K.-M.; Hsu, R.-B.; Yu, H.-Y.; Wang, M.-J. Eight-Year Experience of Intraoperative Aortic Dissection. Asian Cardiovascular and Thoracic Annals 2009, 17, 408–412-408–412. Chen, Y.; Wu, J.M.; Lin, T.Y.; Wu, C.C.; Chiu, K.M.; Chang, B.F.; Tseng, S.H.; Chu, S.H. Tetrandrine ameliorated reperfusion injury of small bowel transplantation. J Pediatr Surg 2009, 44, 2145-2152, doi:10.1016/j.jpedsurg.2009.06.002. Chang, C.Y.; Hung, M.H.; Chang, H.C.; Chan, K.C.; Chen, H.Y.; Fan, S.Z.; Lin, T.Y. Delayed onset of contralateral pulmonary edema following reexpansion pulmonary edema of a collapsed lung after video-assisted thoracoscopic surgery. Acta Anaesthesiol Taiwan 2009, 47, 87-91, doi:10.1016/s1875-4597(09)60030-8. Yang, M.-H.; Wu, C.-C.; Jean, W.-H.; Lu, C.-W.; Chuang, Y.-H.; Lin, T.Y. Spleen Rupture After Mitral Valve Replacement for Infective Endocarditis. Acta Anaesthesiologica Taiwanica 2008, 46, 191–193-191–193. Lin, T.Y.; Chiu, K.M.; Shieh, J.S.; Chu, S.H. Emergency redo mitral valve replacement in a pregnant woman at third trimester: case report and literature review. Circ J 2008, 72, 1715-1717, doi:10.1253/circj.cj-07-0775. Kang, T.-J.; Wu, C.-C.; Lu, C.-W.; Jean, W.-H.; Yang, M.-H.; Lin, T.Y. Acute Myocarditis-related Complete Atrioventricular Block—An Accidental Finding in an Acute Appendicitis Patient. Acta Anaesthesiologica Taiwanica 2008, 46, 138–141-138–141. Chiu, K.M.; Lin, T.Y.; Chu, S.H. Images in cardiovascular medicine. Huge femoral artery pseudoaneurysm. Circulation 2008, 117, 1100, doi:10.1161/circulationaha.107.739359. Chiu, K.M.; Lin, T.Y.; Chen, J.S.; Chu, S.H. Percutaneous cardioplegia delivery using the miniport in minimally invasive mitral valve surgery. Interact Cardiovasc Thorac Surg 2008, 7, 342-343, doi:10.1510/icvts.2007.164194. Chiu, K.M.; Chu, S.H.; Lin, T.Y. Left atrial isomerism with right pulmonary artery thrombosis. Eur J Cardiothorac Surg 2008, 33, 112, doi:10.1016/j.ejcts.2007.09.027. Chiu, K.-M.; Wu, C.-C.; Wang, M.-J.; Lu, C.-W.; Shieh, J.-S.; Lin, T.Y.; Chu, S.-H. Local infusion of bupivacaine combined with intravenous patient-controlled analgesia provides better pain relief than intravenous patient-controlled analgesia alone in patients undergoing minimally invasive cardiac surgery. The Journal of Thoracic and Cardiovascular Surgery 2008, 135, 1348–1352-1348–1352. Chiu, K.-M.; Lin, T.Y.; Chu, S.-H.; Chen, J.-S. Total Laparoscopic Repair for Abdominal Aortic Aneurysm. Journal of the Formosan Medical Association 2008, 107, 667–672-667–672. Lin, T.Y.; Chiu, K.M.; Lu, C.W.; Jean, W.H.; Wang, M.J.; Chu, S.H. Immediate extubation in the operating room after cardiac operations with thoracotomy and sternotomy. Acta Anaesthesiol Taiwan 2007, 45, 3-8. Huang, C.-H.; Lu, C.-W.; Lin, T.Y.; Cheng, Y.-J.; Wang, M.-J. Complications of Intraoperative Transesophageal Echocardiography in Adult Cardiac Surgical Patients—Experience of Two Institutions in Taiwan. Journal of the Formosan Medical Association 2007, 106, 92–95-92–95. Chu, S.H.; Chiu, K.M.; Lin, T.Y.; Chu, T.W.; Yeih, D.F.; Li, A.H. Two donor hearts beat in one chest. Tex Heart Inst J 2007, 34, 230-232. Chiu, K.M.; Li, S.J.; Lin, T.Y.; Chan, C.Y.; Chu, S.H. Innominate artery cannulation for aortic surgery. Asian Cardiovasc Thorac Ann 2007, 15, 348-350, doi:10.1177/021849230701500419. Chiu, K.M.; Chan, H.L.; Chu, S.H.; Lin, T.Y. Carvedilol can restore the multifractal properties of heart beat dynamics in patients with advanced congestive heart failure. Auton Neurosci 2007, 132, 76-80, doi:10.1016/j.autneu.2006.10.008. Lu, C.-W.; Lin, T.Y.; Wang, M.-J. Large Coronary Arteriovenous Fistula to the Main Pulmonary Artery. Anesthesia & Analgesia 2006, 103, 41–42-41–42. Lin, T.; Chen, Y.; Lu, C.; Wang, M. Use of transoesophageal echocardiography during cardiac arrest in patients undergoing elective non-cardiac surgery. British Journal of Anaesthesia 2006, 96, 167–170-167–170. Huang, I.R.; Jean, W.H.; Lu, C.W.; Wu, C.C.; Lin, T.Y.; Chuang, Y.H.; Sun, W.Z. Two different anesthetic managements of a patient with von Gierke's disease. Acta Anaesthesiol Taiwan 2006, 44, 51-53. Chiu, K.M.; Lin, T.Y.; Wang, M.J. Huge right coronary artery aneurysm in a young adult. Eur Heart J 2006, 27, 2195, doi:10.1093/eurheartj/ehi789. Chiu, K.M.; Lin, T.Y.; Li, S.J.; Chen, J.S.; Chu, S.H. Less invasive mitral valve surgery via right minithoracotomy. J Formos Med Assoc 2006, 105, 715-721, doi:10.1016/s0929-6646(09)60199-6. Chiu, K.M.; Lin, T.Y.; Chu, S.H.; Lu, C.W. Managing sternal osteomyelitis with antibiotic bead implantation. Asian Cardiovasc Thorac Ann 2006, 14, e41-42, doi:10.1177/021849230601400233. Chiu, K.M.; Li, S.J.; Chen, J.S.; Lin, T.Y.; Chan, C.Y.; Chu, S.H. Endoscopic radial artery harvest for coronary artery bypass surgery. J Formos Med Assoc 2006, 105, 384-389, doi:10.1016/s0929-6646(09)60134-0. Chiu, K.-M.; Lin, T.Y.; Wang, M.-J.; Chu, S.-H. Reduction of Carbon Dioxide Embolism for Endoscopic Saphenous Vein Harvesting. The Annals of Thoracic Surgery 2006, 81, 1697–1699-1697–1699. Chiu, K.-M.; Lin, T.Y.; Li, S.-J.; Chan, C.-Y.; Chu, S.-H. Surgical Resection of Primary Cardiac Lymphoma. Clinical Lymphoma and Myeloma 2006, 6, 420–421-420–421. Chiu, K.-M.; Lin, T.Y.; Chen, J.-S.; Li, S.-J.; Chan, C.-Y.; Chu, S.-H. Left Ventricle Apical Conduit to Bilateral Subclavian Artery in a Patient With Porcelain Aorta and Aortic Stenosis. Circulation 2006, 113. Chen, Y.; Lin, T.Y.; Chen, J.C.; Yang, H.Z.; Tseng, S.H. GL331, a topoisomerase II inhibitor, induces radiosensitization of human glioma cells. Anticancer Res 2006, 26, 2149-2156. Lin, T.Y.; Chen, Y.; Chiu, K.M.; Lu, C.W.; Jean, W.H.; Horng, F.M.; Chu, S.H. Cell saver does not increase pro-inflammatory cytokine levels and expression of adhesive molecules in the salvaged blood of patients undergoing off-pump coronary artery bypass surgery. Acta Anaesthesiol Taiwan 2005, 43, 211-215. Chiu, K.M.; Lin, T.Y.; Chen, J.S.; Li, S.J.; Chu, S.H. Tricuspid valve replacement with a cryopreserved pulmonary homograft. J Thorac Cardiovasc Surg 2005, 130, e1-2, doi:10.1016/j.jtcvs.2005.07.022. Chiu, K.M.; Chen, J.S.; Yeh, S.J.; Lin, T.Y.; Ma, J.Y.; Li, S.J.; Chu, S.H. Hybrid angioplasty for left pulmonary artery stenosis after total correction of tetralogy of Fallot: report of one case. Acta Paediatr Taiwan 2005, 46, 174-177. Chen, Y.-S.; Yu, H.-Y.; Huang, S.-C.; Chiu, K.-M.; Lin, T.Y.; Lai, L.-P.; Lin, F.-Y.; Wang, S.-S.; Chu, S.-H.; Ko, W.-J. Experience and result of extracorporeal membrane oxygenation in treating fulminant myocarditis with shock: What mechanical support should be considered first? The Journal of Heart and Lung Transplantation 2005, 24, 81–87-81–87. Lin, T.Y.; Chiu, K.M.; Chien, C.Y.; Wang, M.J.; Chu, S.H. Case 1. Right ventricular outflow obstruction caused by metastatic hepatocellular carcinoma. J Clin Oncol 2004, 22, 1152-1153, doi:10.1200/jco.2004.04.151. Jeng, C.S.; Huang, I.R.; Lin, C.P.; Lin, T.Y.; Wang, M.J. Intraoperative bronchospasm after intravenous adenosine during general anesthesia. Acta Anaesthesiol Taiwan 2004, 42, 237-240. Lin, T.Y.; Chiu, K.-M.; Wang, M.-J.; Chu, S.-H. Carbon dioxide embolism during endoscopic saphenous vein harvesting in coronary artery bypass surgery. The Journal of Thoracic and Cardiovascular Surgery 2003, 126, 2011–2015-2011–2015. Chuang, Y.-S.; Hsiao, P.-N.; Lin, T.Y.; Cheng, Y.-J.; Tsai, S.-K. Right upper lobe pulmonary edema after mitral valve replacement caused by paravalvular leakage recognized by bedside transesophageal echocardiography. Critical Care Medicine 2002, 30, 695–696-695–696.