現職

亞東紀念醫院醫學研究部 研究員 (2022-)

核心實驗室

組織纖維化及癌化實驗室

經歷

肝臟幹細胞和再生醫學及腫瘤研究團隊 研究員 (2014-2022)

亞東紀念醫院一般外科 研究員 (2014-2022)

金樺生物醫學有限公司

斯克里普斯研究所 博士後研究人員

The Scripps Research Institute Research Associate

學歷

美國加州大學聖地亞哥分校生物科學 博士

(University of California, San Diego, USA. Ph.D.)

國立台灣大學生化科學所 碩士

國立台灣大學農化系 學士

榮譽/證照/訓練

☆ 2024 經濟部iPAS 初級巨量資料分析師證照

☆ 2024 TQC python 網頁擷取及資料分析證照

☆ 2024 商業數據分析師IBM SPSS 軟體認證

☆ 2022 台灣精準醫療種子人才訓練計畫

☆ 2021 實驗室認證規範ISO/IEC 17025訓練

☆ 2020 乳癌防治基金會第五屆優秀論文佳作獎

☆ 2010 The 36th La Jolla Immunology Conference 優秀海報論文獎

專長領域

癌症細胞生物學、免疫學、組織纖維化、訊息傳遞

個人著作

1. Yen-Ling Chiu, Sui-Hing Yan, Yang-Teng Fan, Chiung-Fang Chang, Ruo-Wei Hung, Yi-Chien Liu, TienYu Owen Yang, Yi-Fang Chuang. Aβ-reactive T cell polyfunctionality response as a new biomarker for mild cognitive impairment. (2025, Jan) Alzheimers Dement (Amst). 17(1):e70042. 2.
2. Li-Jen Liao, Chien-Chen Tsai, Po-Yu Li, Cheng-Yun Lee, Shian-Ren Lin, Wan-Yu Lai, I-Yu Chen, Chiung-Fang Chang, Jan-Mou Lee, Yen-Ling Chiu Y.L. (2024). Characterization of unique pattern of immune cell profile in patients with nasopharyngeal carcinoma through flow cytometry and machine learning. (2024, Jun) J Cell Mol Med 28(12): e18404.
3. Kuo-Shyang Jeng, Chiung-Fang Chang, Yuk-Ming Tsang , I-Shyan Sheen , Chi-Juei Jeng. Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma (2024, April). Cancers, 16(19): 1739
4. Kuo-Shyang Jeng, Po-Yu Cheng, Yueh-Hsien Lin, Po-Chun Liu,Ping-Hui Tseng, Yu-Chao Wang, Chiung-Fang Chang,Chuen-Miin Leu* (2024, Jan). Aldo-keto reductase family member C3 (AKR1C3) promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α. Oncology Research, 32(1): 163-174.
5. Shao-An Wang, Chien-Chieh Hsieh, Chung-Ta Chang, Ping-Wen Huang, Kuang- Chau Tsai, Chun-Bin Tung, Chieh-Min Fan, Ying-Hsin Chang, Jen-Tang Sun, Chun-Yen Huang, Chiung-Fang Chang, San-Fang Chou, Chih-Jung Chang, Kuo-Yang Hsi (2024). The association between total number of days of systemic corticosteroid treatments and outcomes of hospitalized patients with COVID-19. Show Chwan Medical Journal. (Ahead of print)
6. Glemarie C. Hermosa, Chien-Shiun Liao, Ho-Shing Wu, Sea-Fue Wang, Ting-Yu Liu, Kuo-Shyang Jeng, Shu-Sheng Lin, Chiung-Fang Chang*, An-Cheng Aidan Sun*. Green Synthesis of Magnetic Ferrites (Fe3O4, CoFe2O4, and NiFe2O4) Stabilized by Aloe Vera Extract for Cancer Hyperthermia Activities. IEEE Transactions on Magnetics. 2022, Aug 58(8): 1-7. doi: 10.1109/TMAG.2022.3158835 (IF:1.848)
7. I-Ting Chen, An-Chieh Cheng, Yi-Ting Liu, Chieh Yan, Yi-Chen Cheng, Chiung-Fang Chang*, Ping-Hui Tseng*. Persistent TLR4 Activation Promotes Hepatocellular Carcinoma Growth through Positive Feedback Regulation by LIN28A/Let?7g miRNA. Int J Mol Sci. 2022 Jul 29;23(15):8419. doi: 10.3390/ijms23158419. (IF: 6.208)
8. Kuo-Shyang Jeng, Chiung-Fang Chang, I-Shyan Sheen, Chi-Juei Jeng, Chih-Hsuan Wang. Upper Gastrointestinal Cancer and Liver Cirrhosis. Cancers (Basel). 2022 May 2;14(9):2269. doi: 10.3390/cancers14092269. (IF: 6.575)
9. Yi-Wen Tsai, Kuo-Shyang Jeng, Mu-Kuang He, Yang-Wen Hsieh, Hsin-Hung Lai, Chi-Yu Lai, Chun-Chieh Huang, Chiung-Fang Chang, Chung-Tsui Huang, Guor Mour Her. MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis. Cells. 2021 Dec 6;10(12):3434. doi: 10.3390/cells10123434. PMID: 34943942; PMCID: PMC8700344. (IF: 7.666)
10. Kuo-Shyang Jeng, I-Shyan Sheen, Shu-Sheng Lin, Chuen-Miin Leu, Chiung-Fang Chang*. The Role of Endoglin in Hepatocellular Carcinoma. Int J Mol Sci. 2021 Mar 22;22(6):3208. doi: 10.3390/ijms22063208. PMID: 33809908; PMCID: PMC8004096. (IF: 6.208)
11. Kuo-Shyang Jeng, I-Shyan Sheen, Chuen-Miin Leu, Ping-Hui Tseng, Chiung-Fang Chang*. The Role of Smoothened in Cancer. Int J Mol Sci. 2020 Sep 18;21(18):6863. doi: 10.3390/ijms21186863. PMID: 32962123; PMCID: PMC7555769.(IF: 6.208)
12. Kuo-Shyang Jeng, Ssu-Jung Lu, Chih-Hsuan Wang, Chiung-Fang Chang*. Liver Fibrosis and Inflammation under the Control of ERK2. Int J Mol Sci. 2020 May 27;21(11):3796. doi: 10.3390/ijms21113796. PMID: 32471201; PMCID: PMC7312875. (IF: 6.208)
13. Kuo-Shyang Jeng, Chiung-Fang Chang, Shu-Sheng Lin. Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments. Int J Mol Sci. 2020 Jan 23;21(3):758. doi: 10.3390/ijms21030758. PMID: 31979397; PMCID: PMC7037908. (IF: 6.208)
14. Kuo-Shyang Jeng, Chi-Juei Jeng , Wen-Juei Jeng, I-Shyan Sheen, Shih-Yun Li, Chuen-Miin Leu*, Yeou-Guang Tsay, Chiung-Fang Chang.* Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma. Oncol Lett. 2019 Nov;18(5):4377-4384. doi: 10.3892/ol.2019.10826. Epub 2019 Sep 9. PMID: 31611946; PMCID: PMC6781692. (IF: 3.111)
15. Kuo-Shyang Jeng, Chi-Juei Jeng, I-Shyan Sheen, Szu-Hua Wu, Ssu-Jung Lu, Chih-Hsuan Wang, Chiung-Fang Chang*. Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer. Int J Mol Sci. 2018 May 5;19(5):1375. doi: 10.3390/ijms19051375. PMID: 29734730; PMCID: PMC5983844. (IF: 6.208)
16. Kuo-Shyang Jeng, Chi-Juei Jeng, Wen-Juei Jeng, I-Shyan Sheen, Shih-Yun Li, Ssu-Jung Lu, Chiung-Fang Chang*. Tropism of liver epithelial cells toward hepatocellular carcinoma in vitro and in vivo with altering gene expression of cancer stem cells. Am J Surg. 2018 Apr;215(4):735-743. doi: 10.1016/j.amjsurg.2017.11.041. Epub 2017 Dec 6. PMID: 29246405. (IF: 3.125)
17. Kuo-Shyang Jeng, Chi-Juei Jeng, Wen-Juei Jeng, Chiung-Fang Chang, I-Shyan Sheen. Role of C-X-C chemokine ligand 12/C-X-C chemokine receptor 4 in the progression of hepatocellular carcinoma. Oncol Lett. 2017 Aug;14(2):1905-1910. doi: 10.3892/ol.2017.6396. Epub 2017 Jun 16. PMID: 28789425; PMCID: PMC5529928. (IF: 3.111)
18. Yunching Chen, Ya-Chi Liu, Yun-Chieh Sung, Rakesh R. Ramjiawan, Ts-Ting Lin, Chih-Chun Chang, Kuo-Shyang Jeng, Chiung-Fang Chang, Chun-Hung Liu, Dong-Yu Gao, Fu-Fei Hsu, Annique M. Duyverman, Shuji Kitahara, Peigen Huang, Simona Dima, Irinel Popescu, Keith T. Flaherty, Andrew X. Zhu, Nabeel Bardeesy, Rakesh K. Jain, Cyril H. Benes, Dan G. Duda. Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors. Sci Rep. 2017 Mar 9;7:44123. doi: 10.1038/srep44123. PMID: 28276530; PMCID: PMC5343435. (IF: 4.996)
19. Kuo-Shyang Jeng ,Chi-Juei Jeng, Wen-Juei Jeng, I-Shyan Sheen, Shih-Yun Li, Zih-Hang Hung, Hsin-I Hsiau, Ming-Che Yu, Chiung-Fang Chang*. Liver epithelial cells inhibit proliferation and invasiveness of hepatoma cells. Oncol Rep. 2016 Mar;35(3):1622-8. doi: 10.3892/or.2015.4478. Epub 2015 Dec 8. PMID: 26647726. (IF: 4.136)
20. Kuo-Shyang Jeng Chi-Juei Jeng, Wen-Juei Jeng, I-Shyan Sheen, Chiung-Fang Chang, Hsin-I Hsiau, Zih-Hang Hung, Ming-Che Yu, Fang-Yu Chang. Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma. Am J Surg. 2015 Sep;210(3):554-60. doi: 10.1016/j.amjsurg.2015.03.001. Epub 2015 May 8. PMID: 26073903. (IF: 3.125)
21. Kuo-Shyang Jeng, Chiung-Fang Chang, Wen-Juei Jeng, I-Shyan Sheen, Chi-Juei Jeng. Heterogeneity of hepatocellular carcinoma contributes to cancer progression. Crit Rev Oncol Hematol. 2015 Jun;94(3):337-47. doi: 10.1016/j.critrevonc.2015.01.009. Epub 2015 Jan 29. PMID: 25680939. (IF: 6.625)
22. Chiung-Fang Chang, Warren N. D’Souza, Irene L. Ch’en, Gilles Pages, Jacques Pouyssegur, and Stephen M. Hedrick. Polar opposites: Erk direction of CD4 T cell subsets. J Immunol. 2012 Jul 15;189(2):721-31. doi: 10.4049/jimmunol.1103015. Epub 2012 Jun 6. PMID: 22675204; PMCID: PMC3392534. (IF: 5.446)
23. Warren N D'Souza, Chiung-Fang Chang, April M Fischer, Manqing Li, Stephen M Hedrick. The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol. 2008 Dec 1;181(11):7617-29. doi: 10.4049/jimmunol.181.11.7617. PMID: 19017950; PMCID: PMC2847891. (IF: 5.446)
24. Ching-Wen Ho, Yu-Nong Lin, Chuan-Fa Chang, Shiou-Ting Li, Ying-Ta Wu, Chung-Yi Wu, Chiung-Fang Chang, Sheng-Wen Liu, Yaw-Kuen Li, Chun-Hung Li. Discovery of different types of inhibition between the human and thermotoga maritima alpha-fucosidases by fuconojirimycin-based derivatives. Biochemistry. 2006 May 9;45(18):5695-702. doi: 10.1021/bi052559n. PMID: 16669613. (IF: 3.321)
25. Yi-Ying Lee, Chiung-Fang Chang, Chueh-Ling Kuo, Meng-Ching Chen, Chien Hung Yu, Pei-I Lin, and Whi Fin Wu. Subunit oligomerization and substrate recognition of the Escherichia coli ClpYQ (HslUV) protease implicated by in vivo protein-protein interactions in the yeast two-hybrid system. J Bacteriol. 2003 Apr;185(8):2393-401. doi: 10.1128/JB.185.8.2393-2401.2003. Erratum in: J Bacteriol. 2004