現職

亞東紀念醫院 研究副院長

元智大學生技所 教授

台灣再生醫學會 榮譽理事

台灣骨科醫學會 理事

台灣細胞醫療協會 理事

台灣肩肘醫學會 理事

中華民國關節鏡與膝關節醫學會 理事

台灣電腦輔助骨科手術學會常務 理事

經歷

台大醫院骨科部 住院醫師

台大醫院骨科部 總醫師

台大醫院骨科部 研究員

美國梅約醫學中心關節重建部 研究員

台大醫院骨科部 兼任主治醫師

台大醫學院骨科 兼任助理教授

台灣骨科研究學會 常務理事

台灣骨科研究學會 秘書長

台灣再生醫學會 理事

台灣再生醫學會 秘書長

台灣肩肘醫學會 秘書長

台灣骨科創傷醫學會 常務理事

亞東紀念醫院外科部 主任

亞東紀念醫院骨科部關節重建科 主任

亞東紀念醫院骨科部 主任

學歷

國立台灣大學醫學院醫學系 醫學士

國立台灣大學醫學工程研究所 博士

國際外科學院 院士

重要事績

☆ 發明專利三件：

(A) 虹吸式生物反應器 (發明第I286158號)

(B) 具有誘導能力之骨水泥 (發明第I414326號)

(C) 複合性骨水泥 (發明第I414327號)

☆ 執行一件細胞治療之特管辦法，以髕骨下脂肪墊分離幹細胞治療退化性關節炎。

☆ 申請兩件細胞治療之特管辦法。（骨髓幹細胞以治療軟骨缺損、皮下脂肪幹細胞治療退化性關節炎）

☆ 建立再生醫學會網站與臉書，以推廣亞東醫院之細胞治療。

☆ 於衛生福利部以專家立場，協助推廣細胞治療（https://celltherapy.mohw.gov.tw/education.htm）

專長領域

骨折外傷處置

骨質疏鬆症

人工關節置換手術（包含肘,肩,膝,髖,關節）

導航系統輔助精準全膝置換

逆轉式肩關節置換

機器人輔助精準關節置換

肘關節僵化

膝關節軟骨再生（年輕人可免換人工關節）

膝關節肩關節玻尿酸注射

自體血小板生長因子PRP注射

特管辦法幹細胞治療退化性膝關節炎

論文發表

1. Ting-Hui Chang, Chien-Sheng Wu, Shih-Hwa Chiou, Chih-Hung Chang*, Hsiu-Jung Liao*. (2022 May) Adipose-Derived Stem Cell Exosomes as a Novel Anti-Inflammatory Agent and the Current Therapeutic Targets for Rheumatoid Arthritis. Biomedicines. 10(7), 1725.
2. Yu-Hung Chen, Hsiu-Jung Liao, Shang Ming Lin, Chih-Hung Chang, Syang-Peng Rwei, Tsung-Yu Lan. (2022 May) Radiographic outcomes of the treatment of complex femoral shaft fractures (AO/OTA 32-C) with intramedullary nailing: a retrospective analysis of different techniques. Journal of International Medical Research. 50(6) 1–13
3. Yu-Chun Chen*, Hsiu-Jung Liao*, Yuan-Ming Hsu, Yi-Shan Shen, and Chih-Hung Chang. (2022 April) Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model. Ploymers. 14(1474).
4. Chih-Hao Chang*, Chih-Yang Lin, Chih-Hung Chang, Fwu-Hsing Liu, Yu-Tzu Huang, Yunn-Shiuan Liao*. (2022 April) Enhanced biomedical applicability of -ZrO2–SiO2 ceramic composites in 3D printed bone scaffolds. Scientific Reports (12:6845)
5. Chih-Ho Hsu, Chen-Lun Chiu, Yi-Ting Lin, Ann-Yu Yu. Yen-Te Kang, Michael Cherng, Yi-Hui Chen, Ting-Hui Chuang, Hsin-Yi Huang, Jwo-Luen Pao. Kuo-Hsin Chen*, Chih-Hung Chang* (2022 March) Triage admission protocol with a centralized quarantine unit for patients after acute care surgery during the COVID-19 pandemic: A tertiary center experience in Taiwan. PLOS ONE.
6. Hsiu-Jung Liao, Chih-Hung Chang*, Chi-Ying F. Huang and Hui-Ting Chen. (2022 Feb) Potential of Using Infrapatellar–Fat–Pad–Derived Mesenchymal Stem Cells for Therapy in Degenerative Arthritis: Chondrogenesis, Exosomes, and Transcription Regulation. Biomolecules. 12, 386. (SCI)
7. Chih-Hao Chang*, Chih-Hung Chang, Ya-Wen Yang, Hsuan-Yu Chen, Shu-Jyuan Yang, Wei-Cheng Yao and Chi-Yang Chao*. (2022 January) Quaternized Amphiphilic Block Copolymers as Antimicrobial Agents. Polymers. 14(250)
8. Chien-Cheng Lai, Ting-Ming Wang, Chih-Hung Chang, Jwo-Luen Pao, Hsu-Wei Fang, Chih-Hung Chang, Shang-Ming Lin and Tsung-yu Lan*. (2021 Nov) Calcaneal lengthening using ipsilateral fibula autograft in the treatment of symptomatic pes valgus in adolescents. BMC Musculoskeletal Disorders. 22:977. (SCI)
9. Hung-Hsuan Chen, Yu-Chun Chen, San-Ni Yu, Wan-Ling Lai, Pei-Chun Shen, Siao-Han Lin, Chih-Hung Chang*, Shing-Mou Lee*. (2021 Oct) Infrapatellar fat pad–derived mesenchymal stromal cell product for treatment of knee osteoarthritis: a first-in-human study with evaluation of the potency marker. Cytotherapy. (1377) (SCI)
10. Yen-Liang Liu, Chun-Che Yen, Tzu-Shang Thomas Liu, Chih-Hung Chang, Tiffany Ting-Fang Shih, Jyh-Horng Wang, Ming-Chia Yang, Feng-Huei Lin and Hwa-Chang Liu. (2021 Sep) Safety and Efficacy of KartigenR in Treating Cartilage Defects: A Randomized, Controlled, Phase I Trial. Polymers. 13(3029). (SCI)
11. Hwa-Chang Liu, Tzu-Shang Thomas Liu, Yen-Liang Liu, Jyh-Horng Wang, Chih-Hung Chang, Tiffany Ting-Fang Shih, Feng-Huei Lin. (2021 May) Atelocollagen-embedded chondrocyte precursors as a treatment for Grade-4 cartilage defects of the femoral condyle: a case series with up to 9-year follow-up. Biomolecules. 11(7), 942. (SCI)
12. Karl Wu, Yu-Chun Chen, Shang M Lin, Chih-Hung Chang. (2021 May) In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ceramic bone substitute. Journal of Biomaterials Applications.;35(10);1355-1365. (SCI)
13. Chun-Hsing Liao, Chiang Sang Chen, Yu-Chun Chen, Ni-En Jiang, Chui Jia Farn, Yi-Shan Shen, Ming-Lun Hsu, Chih-Hung Chang. (2020 Aug) Vancomycin-loaded oxidized hyaluronic acid and adipic acid dihydrazide hydrogel: Bio-compatibility, drug release, antimicrobial activity, and biofilm model. Journal of Microbiology, Immunology and Infection. 53:525-531. (SCI)
14. Jwo-Luen Pao, Shang-Ming Lin, Wen-Chi Chen, Chih-Hung Chang. (2020 Jun) Unilateral biportal endoscopic decompression for degenerative lumbar canal stenosis, Journal of Spine Surgery. 6(2):438-446. (SCI)
15. Zhen Chang Liang, Mark Seng Ye Chong, Gabriel Ka Po Liu, Alejandro Gonzalez Della Valle, Dahui Wang, Xuemin Lyu, Chih-Hung Chang, Tae-Joon Cho, Steven B. Haas, Dale Fisher, Diarmuid Murphy, James Hoi Po Hui. (2020 May) COVID-19 and Elective Surgery: 7 Practical Tips for a Safe, Successful and Sustainable Reboot.Annals of Surgery: May 20, 2020 - Volume Publish Ahead of Print - Issue – (doi: 10.1097/SLA.0000000000004091) (SCI)
16. Ta-Li Hsu, Shang-Ming Lin, Chih-Hung Chang, Tsung-Yu Lan. (2019 Oct) Neglected Pediatric Osteochondral Fracture Dislocation of the Patella. Case Reports in Orthopedics. 2019:2904782. (SCI)
17. Yu-Chun Chen, Yu-Wei Chang, Kinn Poay Tan, Yi-Shan Shen, Yao- Horng Wang, Chih-Hung Chang*. (2018, Nov) Can mesenchymal stem cells and their conditioned medium assist inflammatory chondrocytes recovery? PLoS ONE.13(11): 0205563.(SCIE)
18. Yu-Chun Chen, Yuan-Ming Hsu, Kinn Poay Tan, Hsu-Wei Fang, Chih-Hung Chang*. (2018, Oct) Intraarticular injection for rabbit knee osteoarthritis: effectiveness among hyaluronic acid, platelet-rich plasma, and mesenchymal stem cells. Journal of the Taiwan Institute of Chemical Engineers. 91, 138-145. (SCI)
19. Cheng-Tzu Wang, Jia-Wan Chen, Karl Wu, Chih-Hung Chang, Wen-Chih Chen, Jwo-Luen Pao, Chih-Hung Chang and Tsung-Yu Lan. (2018 Jun) Suboptimal outcomes after closed reduction and internal fixation of displaced femoral neck fractures in middle-aged patients Is internal fixation adequate in this age group. BMC Musculoskeletal Disorders, 9;19(1):190. (SCIE)
20. Chih-Kai Hong, Ming-Long Yeh, I-Ming Jou, Cheng-Li Lin, Chih-Hsun Chang, Chih-Hung Chang, Wei-Ren Su (2018 May). The effect of humeral-fenestration diameter in Outerbridge–Kashiwagi arthroplasty on failure load of the distal humerus: a cadaveric biomechanical study. Archives of Orthopaedic and Trauma Surgery, 138(5):623-628. (SCIE)
21. Chia Chun Chen, Chu Yun Hsiao, Yao Horng Wang, Yu Chun Chen, Chih Hung Chang, Hsu Wei Fang. (2017 Sep) A comparison of distinct bone marrow-derived cells on cartilage tissue engineering. Journal of the Taiwan Institute of Chemical Engineers; 78:32-38. (SCI)
22. Yeong-Jang Chen, Jwo-luen Pao, Chiang Sang Chen, Yu-Chun Chen, Chun-Chien Chang, Fang-Ming Hung, and Chih Hung Chang. (2017 Jan). Evaluation of New Biphasic Calcium Phosphate Bone Substitute: Rabbit Femur Defect Model and Preliminary Clinical Results. J Med Biol Eng. 2017; 37(1): 85–93. (SCI)
23. Karl Wu, Yu-Chun Chen, Yuan-Ming Hsu, Chih Hung Chang*. (2016 March) Enhancing Drug Release from Antibiotic-loaded Bone Cement Using Porogens. Journal of the American Academy of Orthopaedic Surgeons, 24(3): 188–195. (SCI)
24. Yuan-Ming Hsu, Chun-Hsing Liao, Yu-Hong Wei, Hsu-Wei Fang, Hsiang-Huan Hou, Chia-Chun Chen and Chih Hung Chang*. (2014 Jun). Daptomycin-loaded polymethylmethacrylate bone cement for joint arthroplasty surgery. Artificial Organs, 38(6):484-92 (SCI)
25. Chih Hung Chang*, Yuan-Ming Hsu, Yu-Chun Chen, Feng-Huei Lin, Subramaniam Sadhasivam, Siow-Tung Loo, Sivasubramanian Savitha. (2014 Apr). Anti-Inflammatory effects of hydrophilic and lipophilic statins with hyaluronic acid against LPS-induced inflammation in porcine articular chondrocytes. Journal of Orthopaedic Research, 32(4): 557-65. (SCI)
26. Chih Hung Chang*, Chia-Chun Chen, Cheng-Hao Liao, Feng-Huei Lin, Yuan-Ming Hsu and Hsu-Wei Fang (2014, Jul). Human acellular cartilage matrix powders as a biological scaffold for cartilage tissue engineering with synovium-derived mesenchymal stem cells. Journal of Biomedical Materials Research: Part A, 102A: 2248-2257. (SCI)
27. Jwo-Luen Pao; Wen-Chih Chen; Chih Hung Chang; Chiang-Sang Chen; Jaw-Lin Wang. 2014, Dec. Clinical Significance of Post-decompression Facet Joint Effusion After Minimally Invasive Decompression for Degenerative Lumbar Spinal Stenosis. Journal of Spinal Disorders and Techniques. 27(8): E318–E323 (SCI)
28. Wei-Chuan Chen, Wan-Ju Yu, Chia-Che Chang, Jo-Shu Chang, Shih-Horng Huang, Chih Hung Chang, Shan-Yu Chen*, Chih-Ching Chien, Chao-Ling Yao, Wen-Ming Chen, and Yu-Hong Wei*. 2013, Sep. Enhancing production of prodigiosin from Serratia marcescens C3 by statistical experimental design and porous carrier addition strategy. Biochemical Engineering Journal, 78(15): 93-100. (SCI)
29. Tsung-Ching Lin, Hsing-Kuo Wang, Jia-Wine Chen, Cheng-Ming Chiu, Hsiu-Ling Chou, Chih Hung Chang*. 2013. May. Minimally invasive knee arthroplasty with the subvastus approach allows rapid rehabilitation: a prospective, biomechanical, and observational study. Journal of Physical Therapy Science, 25(5): 55-5627. (SCI)
30. Chia-Chun Chen, Cheng-Hao Liao, Yao-Horng Wang, Yuan-Ming Hsu, Shih-Horng Huang, Chih Hung Chang*, Hsu-Wei Fang*. 2012, Mar. Cartilage fragments from osteoarthritic knee promote chondrogenesis of mesenchymal stem cells without exogenous growth factor induction. Journal of Orthopaedic Research, 30(3): 393-400. (SCI)
31. Tsung-Yu Lan, Wei-Hsin Lin, Jih-Hsin Huang, Chih Hung Chang, Rong-Sen Yang, Jui-Sheng Sun, Chih-Yu Chen*. 2012, Apr. Traumatic femoral vein rupture with compartment syndrome with concomitant closed femoral diaphyseal fracture: a case report. The Journal of Bone and Joint Surgery-American Volume, 2(2): e18 1-4. (SCI)
32. Chih Hung Chang, Hsin-Chun Lee, Chia-Chun Chen, Yi-Hau Wu, Yuan-Ming Hsu, Yin-Pen Chang, Ta-I Yang, Hsu-Wei Fang*. 2012, Jul. A novel rotating electrochemically anodizing process to fabricate titanium oxide surface nanostructures enhancing the bioactivity of osteoblastic cells. Journal of Biomedical Matrials Research PART A, 100(7): 1687-95. (SCI)
33. Wen-Chih Huang*, Chih Hung Chang, Chien-Chen Tsai. 2012, Jan. Polyvinylpyrrolidone storage disease presenting as pathologic fracture and anemia: report of a case with imprint cytology. Diagnostic Cytopathology, 40(1): 69-72 (SCIE)
34. Karl Wu, Chih Hung Chang*, Rong-Sen Yang. 2011, Nov. Comparing hook plates and Kirschner tension band wiring for unstable lateral clavicle fractures. Orthopedics, 34(11): e718-e723. (SCIE)
35. Hsin-Hua Liu, Karl Wu, Chih Hung Chang*. 2011, May. Treatment of complex elbow injuries with a postoperative custom-made progressive stretching static elbow splint. Journal of Trauma-Injury Infection and Critical Care, 70(5): 1268-1272. (SCIE)
36. Chih Hung Chang, Tzong-Fu Kuo, Feng-Huei Lin, Jyh-Horng Wang, Yuan-Ming Hsu, Huei-Ting Huang, Shiao-Tung Loo, Hsu-Wei Fang, Hwa-Chang Liu*, Wen-Chih Wang. 2011, Dec. Tissue engineering-based cartilage repair with mesenchymal stem cells in a porcine model. Journal of Orthopaedic Research, 29(12): 1874-80. (SCI)
37. Shiu-Dong Chung, Chih Hung Chang, Wu K, Chu SH. 2011, Jan. Post-acupuncture shoulder swelling. QJM –An international journal of medicine, 105(3): 281-282. (SCI)
38. Hsin-Hua Liu*, Chih Hung Chang, Wei-Tso Chia, Chi-Hui Chen, Yi-Wen Tarng, Chi-Yin Wong. 2010, Dec. Comparison of plates versus intramedullary nails for fixation of displaced midshaft clavicular fractures. Journal of Trauma-Injury Infection and Critical Care, 69(6): e82-87. (SCIE)
39. Chih-Yu Chen, Chih Hung Chang, Yung-Chang Lu, Chih-Hung Chang*, Chien-Chen Tsai, Chun-Hsiung Huang. 2010, Nov. Late foreign-body reaction after treatment of distal radial fractures with poly-L-lactic acid bioabsorbable implants: a report of three cases. The Journal of Bone and Joint Surgery-American Volume, 92(16): 2719-2724. (SCI)
40. Chih Hung Chang*, Hsu-Wei Fang, Yi-Ching Ho, Chun-Yen Lin, Chun-Hsiung Huang, Charng-Bin Yang. 2010, Aug. Combined effects of polyethylene wear particle size and dosage on macrophage responses. Biomedical Engineering-Applications Basis Communications, 22 (4): 279-291. (SCIE)
41. Chih Hung Chang, Rong-Sen Yang, Kuang-Ho Chen, Tang-Kue Liu, Wen-Chih Chen, Yi-Ching Ho, Sheng-Mou Hou*. 2010, Jul. Muscle torque in total knee arthroplasty: comparison of subvastus and midvastus approaches. Knee Surgery Sports traumatology Arthroscopy, 18(7): 934-938. (SCI)
42. Chih Hung Chang, Tai-Chieh Liao, Yuan-Ming Hsu, Hsu-Wei Fang, Chia-Chun Chen, Feng-Huei Lin*. 2010, May. A poly (propylene fumarate)-calcium phosphate based angiogenic injectable bone cement for femoral head osteonecrosis. Biomaterials, 31(14): 4048-4055. (SCI)
43. Chih Hung Chang, Siow-Tung Loo, Hsuan-Liang Liu, Hsu-Wei Fang, Hsin-Yi Lin*. 2010, Mar. Can low frequency electromagnetic field help cartilage tissue engineering? Journal of Biomedical Materials Research: Part A, 92(3): 843-851. (SCI)
44. Chih Hung Chang, Hsin-Yi Lin, Hsu-Wei Fang, Siow-Tung Loo, Shih-Chieh Hung, Yi-Ching Ho, Chia-Chun Chen, Feng-Huei Lin* and Hwa-Chang Liu* (2008, Jul). Chondrogenesis from immortalized human mesenchymal stem cells: comparison between collagen gel and pellet culture methods. Artificial Organs, 32(7): 561-566. (SCI)
45. Chih Hung Chang, Hsu-Wei Fang*, Yi-Ching Ho, Huei-Ting Huang (2008, May). Chondrocyte acting as phagocyte to internalize polyethylene wear particles and leads to the elevations of osteoarthritis associated NO and PGE2. Biochemical and Biophysical Research Communications, 369(3): 884-888. (SCI)
46. Ming-Hsiao Hu, Wen-Chih Chen* and Chih Hung Chang (2008, Jan). Idiopathic osteonecrosis of the third metacarpal head. Journal of the Formosan Medical Association, 107(1): 89-92. (SCI)
47. Chih Hung Chang, Hsu-Wei Fang*, Huei-Ting Huang, Hsuan-Liang Liu, Wei-Ming Lee, Man-Ching Hsieh, Chiang-San Chen (2007, Jun). Tribological process induced conformational transformation of protein may change the friction of articular cartilage. Materials Letters, 61(16): 3381-3384. (SCI)
48. Hsu-Wei Fang*, Meng-Lin Shih, Jian-Hua Zhao, Huei-Ting Huan, Hsin-Yi Lin, Hsuan-Liang Liu, Chih Hung Chang, Charng-Bin Yang, Hwa-Chang Liu (2007, Jun). Association of polyethylene friction and thermal unfolding of interfacial albumin molecules. Applied Surface Science, 253(16): 6896-6904. (SCI)
49. Charng-Bin Yang, Hsu-Wei Fang*, Hsuan-Liang Liu, Chih Hung Chang, Man-Ching Hsieh, Wei-Ming Lee, Huei-Ting Huang (2006, Nov). Frictional characteristics of the tribological unfolding albumin for polyethylene and cartilage. Chemical Physicals Letters, 431(4-6): 380-384. (SCI)
50. Hsu-Wei Fang*, Charng-Bin Yang, Chih Hung Chang, Chun-Hsiung Huang, Hsuan-Liang Liu, Shu-Bin Fang (2006, Nov). The Potential Role of Phagocytic Capacity in the Osteolytic Process Induced by Polyethylene Wear Particles. Journal of International Medical Research, 34(6): 655-664. (SCI)
51. Cheng-Hung Chou, Winston T. K. Cheng, Chien-Cheng Lin, Chih Hung Chang, Chien-Chen Tsai and Feng-Huei Lin* (2006, May). TGF-beta1 immobilized tri-co-polymer for articular cartilage tissue engineering. Journal of Biomedical Materials Research: Part B, 77B (2): 338-348. (SCI)
52. Chih Hung Chang, Tzong-Fu Kuo, Chien-Cheng Lin, Cheng-Hung Chou, Kuang-Ho Chen, Feng-Huei Lin* and Hwa-Chang Liua* (2006, May). Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin-chondroitin-hyaluronan tri-copolymer scaffold: A porcine model assessed at 18, 24, and 36 weeks. Biomaterials., 27(9): 1876-1888. (SCI)
53. Chih Hung Chang, Feng-Huei Lin, Chien-Cheng Lin, Cheng-Hung Chou and Hwa-Chang Liu* (2004, Nov). Cartilage tissue engineering on the surface of a novel gelatin-calcium-phosphate biphasic scaffold in a double-chamber bioreactor. Journal of Biomedical Materials Research: Part B, 71(2):313-21. (SCI)
54. Chih Hung Chang, Hwa-Chang Liu, Chien-Cheng Lin, Cheng-Hung Chou, Feng-Huei Lin* (2003, Nov). Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering. Biomaterials, 24(26): 4853-4858. (SCI)
55. Chih Hung Chang, Kuang-Ho Chen, Rong-Sen Yang, Tang-Kue Liu (2002, May). Muscle Torques in Total Knee Arthroplasty with Subvastus and Parapatellar Approaches. Clinical orthopaedics and related research, 398: 189-195. (SCI)
56. J-S Sun, T T-F Shih, C-M Ko, C-H Chang, Y S Hang, S-M Hou. (2000) In Vivo Kinematic Study of Normal Wrist Motion: An Ultrafast Computed Tomographic Study. Clin Biomech 15:212-6. (SCI)
57. Chih Hung Chang, Yi-Shiun Tsai, Jui-Sheng Sun, Sheng-Mou Hou (2000) Ipsilateral Distal Radius and Scaphoid Fractures. J Formos Med Assoc. 99: 733-7. (SCI)
58. Chih Hung Chang and Shier-Chieg Huang: Clubfoot Deformity in Congenital Constriction Band Syndrome: Manifestations and Treatment (1998) J Formos Med Assoc 97:328-34. (SCI)
59. Chih Hung Chang and Ching-Chuan Jiang (1997): Evaluation of Critical Postoperative Situations in Orthopedic Patients. J Formos Med Assoc 96: 990-5. (SCI)