實驗室簡介

退化性關節炎和軟骨缺損一直以來都是骨骼肌肉系統疾病中難以治癒的重大挑戰。這些疾病不僅影響著患者的生活質量，還造成他們的日常活動和運動能力造成了嚴重限制。為了應對這一挑戰，我們的實驗室致力於深入研究再生醫學和軟骨分化的機制，以開發創新的治療方法。我們的研究核心之一是專注於體內再生能力的探索。

我們致力於了解人體內自然的修復機制，特別是關節和軟骨組織的再生過程。我們研究的重點之一是來自髕骨下脂肪組織的幹細胞。這些幹細胞具有出色的分化潛力，並且在細胞治療和再生醫學中有巨大的應用潛力。我們的研究不僅關注如何從這些幹細胞中分離出高效價幹細胞，還包括研究它們在臨床治療中的應用，以及探索幹細胞衍生物外泌體的潛在作用。

 

我們的研究團隊積極尋求創新解決方案，並已成功申請了美國專利，涵蓋了幹細胞衍生物外泌體和細胞標誌的領域。這些成就反映了我們在科學研究和醫學領域的卓越表現。此外，我們的研究不僅關注退化性關節炎病患，還將目光投向寵物市場和臨床應用。我們與台灣知名生物技術公司合作，致力於開發新的治療項目，以改善寵物的健康狀況，同時擴展我們的研究成果，創造更多的產品價值。

 

我們的團隊由優秀的骨科主治醫師和研究熱忱的研究員組成，共同努力實現再生醫學產品的開發。近年來，我們也積極投入自體免疫疾病類風濕性關節炎的研究，旨在深入瞭解間質幹細胞和細胞衍生物在抗發炎和促進軟骨再生方面的功效和機制。我們熱切歡迎對這一領域有濃厚興趣的專業人士加入我們的團隊，共同攜手解決這些挑戰，為患者帶來更好的健康和生活品質。

團隊成員

團隊主持人 張至宏 副院長
主治醫師 林凱旋 醫師
研究員 廖秀蓉 博士
研究助理 沈宜珊
研究助理 江妮恩
研究助理 盧賜蓉
研究助理 陳柏諺

 

合作單位

國立陽明交通大學 黃奇英 特聘教授
國立陽明交通大學 李利 玉山學者/教授
國立台北科技大學 方旭偉 特聘教授

目前執行大型計畫

國科會整合型計畫

開發膝關節脂肪墊幹細胞輔以間葉幹細胞外泌體之綜合療法-開發膝關節脂肪墊幹細胞輔以間葉幹細胞外泌體之綜合療法（四年計畫）

亞東醫院創新計畫

響應台灣精準醫療計畫與再生製劑草案推動細胞治療: 建立膝關節脂肪墊之幹細胞之異體細胞庫並開發新藥新計畫 （三年計畫）

特定醫療技術檢查檢驗醫療儀器施行或使用管理辦法（簡稱特管辦法）

細胞治療執行項目

1. 自體脂肪間質幹細胞移植

   細胞來源：髕骨下脂肪墊

   適應症：退化性關節炎

2. 自體脂肪間質幹細胞移植

   細胞來源：皮下脂肪

   適應症：退化性關節炎

3. 自體脂肪間質幹細胞移植

   適應症：膝關節軟骨缺損

論文發表

1. Ting-Hui Chang, Chien-Sheng Wu, Shih-Hwa Chiou, Chih-Hung Chang*, Hsiu-Jung Liao*. (2022 May) Adipose-Derived Stem Cell Exosomes as a Novel Anti-Inflammatory Agent and the Current Therapeutic Targets for Rheumatoid Arthritis. Biomedicines. 10(7), 1725.
2. Yu-Hung Chen, Hsiu-Jung Liao, Shang Ming Lin, Chih-Hung Chang, Syang-Peng Rwei, Tsung-Yu Lan. (2022 May) Radiographic outcomes of the treatment of complex femoral shaft fractures (AO/OTA 32-C) with intramedullary nailing: a retrospective analysis of different techniques. Journal of International Medical Research. 50(6) 1–13
3. Yu-Chun Chen*, Hsiu-Jung Liao*, Yuan-Ming Hsu, Yi-Shan Shen, and Chih-Hung Chang. (2022 April) Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model. Ploymers. 14(1474).
4. Chih?Hao Chang*, Chih?Yang Lin, Chih?Hung Chang, Fwu?Hsing Liu, Yu?Tzu Huang, Yunn?Shiuan Liao*. (2022 April) Enhanced biomedical applicability of -ZrO2–SiO2 ceramic composites in 3D printed bone scaffolds. Scientific Reports (12:6845)
5. Chih-Ho Hsu, Chen-Lun Chiu, Yi-Ting Lin, Ann-Yu Yu. Yen-Te Kang, Michael Cherng, Yi-Hui Chen, Ting-Hui Chuang, Hsin-Yi Huang, Jwo-Luen Pao. Kuo-Hsin Chen*, Chih-Hung Chang* (2022 March) Triage admission protocol with a centralized quarantine unit for patients after acute care surgery during the COVID-19 pandemic: A tertiary center experience in Taiwan. PLOS ONE.
6. Hsiu-Jung Liao, Chih-Hung Chang*, Chi-Ying F. Huang and Hui-Ting Chen. (2022 Feb) Potential of Using Infrapatellar–Fat–Pad–Derived Mesenchymal Stem Cells for Therapy in Degenerative Arthritis: Chondrogenesis, Exosomes, and Transcription Regulation. Biomolecules. 12, 386. (SCI)
7. Chih-Hao Chang*, Chih-Hung Chang, Ya-Wen Yang, Hsuan-Yu Chen, Shu-Jyuan Yang, Wei-Cheng Yao and Chi-Yang Chao*. (2022 January) Quaternized Amphiphilic Block Copolymers as Antimicrobial Agents. Polymers. 14(250)
8. Chien?Cheng Lai, Ting?Ming Wang, Chih?Hung Chang, Jwo?Luen Pao, Hsu?Wei Fang, Chun?Chien Chang, Shang?Ming Lin and Tsung?yu Lan*. (2021 Nov) Calcaneal lengthening using ipsilateral fibula autograft in the treatment of symptomatic pes valgus in adolescents. BMC Musculoskeletal Disorders. 22:977. (SCI)
9. Hung-Hsuan Chen, Yu-Chun Chen, San-Ni Yu, Wan-Ling Lai, Pei-Chun Shen, Siao-Han Lin, Chih-Hung Chang*, Shing-Mou Lee*. (2021 Oct) Infrapatellar fat pad–derived mesenchymal stromal cell product for treatment of knee osteoarthritis: a first-in-human study with evaluation of the potency marker. Cytotherapy. (1377) (SCI)
10. Yen-Liang Liu, Chun-Che Yen, Tzu-Shang Thomas Liu, Chih-Hung Chang, Tiffany Ting-Fang Shih, Jyh-Horng Wang, Ming-Chia Yang, Feng-Huei Lin and Hwa-Chang Liu. (2021 Sep) Safety and Efficacy of KartigenR in Treating Cartilage Defects: A Randomized, Controlled, Phase I Trial. Polymers. 13(3029). (SCI)
11. Hwa-Chang Liu, Tzu-Shang Thomas Liu, Yen-Liang Liu, Jyh-Horng Wang, Chih-Hung Chang, Tiffany Ting-Fang Shih, Feng-Huei Lin. (2021 May) Atelocollagen-embedded chondrocyte precursors as a treatment for Grade-4 cartilage defects of the femoral condyle: a case series with up to 9-year follow-up. Biomolecules. 11(7), 942. (SCI)
12. Karl Wu, Yu-Chun Chen, Shang M Lin, Chih-Hung Chang. (2021 May) In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ceramic bone substitute. Journal of Biomaterials Applications.;35(10);1355-1365. (SCI)
13. Chun-Hsing Liao, Chiang Sang Chen, Yu-Chun Chen, Ni-En Jiang, Chui Jia Farn, Yi-Shan Shen, Ming-Lun Hsu, Chih-Hung Chang. (2020 Aug) Vancomycin-loaded oxidized hyaluronic acid and adipic acid dihydrazide hydrogel: Bio-compatibility, drug release, antimicrobial activity, and biofilm model. Journal of Microbiology, Immunology and Infection. 53:525-531. (SCI)
14. Jwo-Luen Pao, Shang-Ming Lin, Wen-Chi Chen, Chih-Hung Chang. (2020 Jun) Unilateral biportal endoscopic decompression for degenerative lumbar canal stenosis, Journal of Spine Surgery. 6(2):438-446. (SCI)
15. Zhen Chang Liang, Mark Seng Ye Chong, Gabriel Ka Po Liu, Alejandro Gonzalez Della Valle, Dahui Wang, Xuemin Lyu, Chih-Hung Chang, Tae-Joon Cho, Steven B. Haas, Dale Fisher, Diarmuid Murphy, James Hoi Po Hui. (2020 May) COVID-19 and Elective Surgery: 7 Practical Tips for a Safe, Successful and Sustainable Reboot.Annals of Surgery: May 20, 2020 - Volume Publish Ahead of Print - Issue – (doi: 10.1097/SLA.0000000000004091) (SCI)
16. Ta-Li Hsu, Shang-Ming Lin, Chih-Hung Chang, Tsung-Yu Lan. (2019 Oct) Neglected Pediatric Osteochondral Fracture Dislocation of the Patella. Case Reports in Orthopedics. 2019:2904782. (SCI)
17. Yu-Chun Chen, Yu-Wei Chang, Kinn Poay Tan, Yi-Shan Shen, Yao- Horng Wang, Chih-Hung Chang*. (2018, Nov) Can mesenchymal stem cells and their conditioned medium assist inflammatory chondrocytes recovery? PLoS ONE.13(11): 0205563.(SCIE)
18. Yu-Chun Chen, Yuan-Ming Hsu, Kinn Poay Tan, Hsu-Wei Fang, Chih-Hung Chang*. (2018, Oct) Intraarticular injection for rabbit knee osteoarthritis: effectiveness among hyaluronic acid, platelet-rich plasma, and mesenchymal stem cells. Journal of the Taiwan Institute of Chemical Engineers. 91, 138-145. (SCI)
19. Cheng-Tzu Wang, Jia-Wan Chen, Karl Wu, Chiang-Sang Chen, Wen-Chih Chen, Jwo-Luen Pao, Chih-Hung Chang and Tsung-Yu Lan. (2018 Jun) Suboptimal outcomes after closed reduction and internal fixation of displaced femoral neck fractures in middle-aged patients Is internal fixation adequate in this age group. BMC Musculoskeletal Disorders, 9;19(1):190. (SCIE)
20. Chih?Kai Hong, Ming?Long Yeh, I?Ming Jou, Cheng?Li Lin, Chih?Hsun Chang, Chih?Hung Chang, Wei?Ren Su (2018 May). The effect of humeral-fenestration diameter in Outerbridge–Kashiwagi arthroplasty on failure load of the distal humerus: a cadaveric biomechanical study. Archives of Orthopaedic and Trauma Surgery, 138(5):623-628. (SCIE)
21. Chia Chun Chen, Chu Yun Hsiao, Yao Horng Wang, Yu Chun Chen, Chih Hung Chang, Hsu Wei Fang. (2017 Sep) A comparison of distinct bone marrow-derived cells on cartilage tissue engineering. Journal of the Taiwan Institute of Chemical Engineers; 78:32-38. (SCI)
22. Yeong-Jang Chen, Jwo-luen Pao, Chiang Sang Chen, Yu-Chun Chen, Chun-Chien Chang, Fang-Ming Hung, and Chih-Hung Chang. (2017 Jan). Evaluation of New Biphasic Calcium Phosphate Bone Substitute: Rabbit Femur Defect Model and Preliminary Clinical Results. J Med Biol Eng. 2017; 37(1): 85–93. (SCI)
23. Karl Wu, Yu-Chun Chen, Yuan-Ming Hsu, Chih-Hung Chang*. (2016 March) Enhancing Drug Release from Antibiotic-loaded Bone Cement Using Porogens. Journal of the American Academy of Orthopaedic Surgeons, 24(3): 188–195. (SCI)
24. Yuan-Ming Hsu, Chun-Hsing Liao, Yu-Hong Wei, Hsu-Wei Fang, Hsiang-Huan Hou, Chia-Chun Chen and Chih-Hung Chang*. (2014 Jun). Daptomycin-loaded polymethylmethacrylate bone cement for joint arthroplasty surgery. Artificial Organs, 38(6):484-92 (SCI)
25. Chih-Hung Chang*, Yuan-Ming Hsu, Yu-Chun Chen, Feng-Huei Lin, Subramaniam Sadhasivam, Siow-Tung Loo, Sivasubramanian Savitha. (2014 Apr). Anti-Inflammatory effects of hydrophilic and lipophilic statins with hyaluronic acid against LPS-induced inflammation in porcine articular chondrocytes. Journal of Orthopaedic Research, 32(4): 557-65. (SCI)
26. Chih-Hung Chang*, Chia-Chun Chen, Cheng-Hao Liao, Feng-Huei Lin, Yuan-Ming Hsu and Hsu-Wei Fang (2014, Jul). Human acellular cartilage matrix powders as a biological scaffold for cartilage tissue engineering with synovium-derived mesenchymal stem cells. Journal of Biomedical Materials Research: Part A, 102A: 2248-2257. (SCI)
27. Jwo-Luen Pao; Wen-Chih Chen; Chih-Hung Chang; Chiang-Sang Chen; Jaw-Lin Wang. 2014, Dec. Clinical Significance of Post-decompression Facet Joint Effusion After Minimally Invasive Decompression for Degenerative Lumbar Spinal Stenosis. Journal of Spinal Disorders and Techniques. 27(8): E318–E323 (SCI)
28. Wei-Chuan Chen, Wan-Ju Yu, Chia-Che Chang, Jo-Shu Chang, Shih-Horng Huang, Chih-Hung Chang, Shan-Yu Chen*, Chih-Ching Chien, Chao-Ling Yao, Wen-Ming Chen, and Yu-Hong Wei*. 2013, Sep. Enhancing production of prodigiosin from Serratia marcescens C3 by statistical experimental design and porous carrier addition strategy. Biochemical Engineering Journal, 78(15): 93-100. (SCI)
29. Tsung-Ching Lin, Hsing-Kuo Wang, Jia-Wine Chen, Cheng-Ming Chiu, Hsiu-Ling Chou, Chih-Hung Chang*. 2013. May. Minimally invasive knee arthroplasty with the subvastus approach allows rapid rehabilitation: a prospective, biomechanical, and observational study. Journal of Physical Therapy Science, 25(5): 55-5627. (SCI)
30. Chia-Chun Chen, Cheng-Hao Liao, Yao-Horng Wang, Yuan-Ming Hsu, Shih-Horng Huang, Chih-Hung Chang*, Hsu-Wei Fang*. 2012, Mar. Cartilage fragments from osteoarthritic knee promote chondrogenesis of mesenchymal stem cells without exogenous growth factor induction. Journal of Orthopaedic Research, 30(3): 393-400. (SCI)
31. Tsung-Yu Lan, Wei-Hsin Lin, Jih-Hsin Huang, Chih-Hung Chang, Rong-Sen Yang, Jui-Sheng Sun, Chih-Yu Chen*. 2012, Apr. Traumatic femoral vein rupture with compartment syndrome with concomitant closed femoral diaphyseal fracture: a case report. The Journal of Bone and Joint Surgery-American Volume, 2(2): e18 1-4. (SCI)
32. Chih-Hung Chang, Hsin-Chun Lee, Chia-Chun Chen, Yi-Hau Wu, Yuan-Ming Hsu, Yin-Pen Chang, Ta-I Yang, Hsu-Wei Fang*. 2012, Jul. A novel rotating electrochemically anodizing process to fabricate titanium oxide surface nanostructures enhancing the bioactivity of osteoblastic cells. Journal of Biomedical Matrials Research PART A, 100(7): 1687-95. (SCI)
33. Wen-Chih Huang*, Chih-Hung Chang, Chien-Chen Tsai. 2012, Jan. Polyvinylpyrrolidone storage disease presenting as pathologic fracture and anemia: report of a case with imprint cytology. Diagnostic Cytopathology, 40(1): 69-72 (SCIE)
34. Karl Wu, Chih-Hung Chang*, Rong-Sen Yang. 2011, Nov. Comparing hook plates and Kirschner tension band wiring for unstable lateral clavicle fractures. Orthopedics, 34(11): e718-e723. (SCIE)
35. Hsin-Hua Liu, Karl Wu, Chih-Hung Chang*. 2011, May. Treatment of complex elbow injuries with a postoperative custom-made progressive stretching static elbow splint. Journal of Trauma-Injury Infection and Critical Care, 70(5): 1268-1272. (SCIE)
36. Chih-Hung Chang, Tzong-Fu Kuo, Feng-Huei Lin, Jyh-Horng Wang, Yuan-Ming Hsu, Huei-Ting Huang, Shiao-Tung Loo, Hsu-Wei Fang, Hwa-Chang Liu*, Wen-Chih Wang. 2011, Dec. Tissue engineering-based cartilage repair with mesenchymal stem cells in a porcine model. Journal of Orthopaedic Research, 29(12): 1874-80. (SCI)
37. Shiu-Dong Chung, Chih-Hung Chang, Wu K, Chu SH. 2011, Jan. Post-acupuncture shoulder swelling. QJM –An international journal of medicine, 105(3): 281-282. (SCI)
38. Hsin-Hua Liu*, Chih-Hung Chang, Wei-Tso Chia, Chi-Hui Chen, Yi-Wen Tarng, Chi-Yin Wong. 2010, Dec. Comparison of plates versus intramedullary nails for fixation of displaced midshaft clavicular fractures. Journal of Trauma-Injury Infection and Critical Care, 69(6): e82-87. (SCIE)
39. Chih-Yu Chen, Chih-Hao Chang, Yung-Chang Lu, Chih-Hung Chang*, Chien-Chen Tsai, Chun-Hsiung Huang. 2010, Nov. Late foreign-body reaction after treatment of distal radial fractures with poly-L-lactic acid bioabsorbable implants: a report of three cases. The Journal of Bone and Joint Surgery-American Volume, 92(16): 2719-2724. (SCI)
40. Chih-Hung Chang*, Hsu-Wei Fang, Yi-Ching Ho, Chun-Yen Lin, Chun-Hsiung Huang, Charng-Bin Yang. 2010, Aug. Combined effects of polyethylene wear particle size and dosage on macrophage responses. Biomedical Engineering-Applications Basis Communications, 22 (4): 279-291. (SCIE)
41. Chih-Hung Chang, Rong-Sen Yang, Kuang-Ho Chen, Tang-Kue Liu, Wen-Chih Chen, Yi-Ching Ho, Sheng-Mou Hou*. 2010, Jul. Muscle torque in total knee arthroplasty: comparison of subvastus and midvastus approaches. Knee Surgery Sports traumatology Arthroscopy, 18(7): 934-938. (SCI)
42. Chih-Hung Chang, Tai-Chieh Liao, Yuan-Ming Hsu, Hsu-Wei Fang, Chia-Chun Chen, Feng-Huei Lin*. 2010, May. A poly (propylene fumarate)-calcium phosphate based angiogenic injectable bone cement for femoral head osteonecrosis. Biomaterials, 31(14): 4048-4055. (SCI)
43. Chih-Hung Chang, Siow-Tung Loo, Hsuan-Liang Liu, Hsu-Wei Fang, Hsin-Yi Lin*. 2010, Mar. Can low frequency electromagnetic field help cartilage tissue engineering? Journal of Biomedical Materials Research: Part A, 92(3): 843-851. (SCI)
44. Chih-Hung Chang, Hsin-Yi Lin, Hsu-Wei Fang, Siow-Tung Loo, Shih-Chieh Hung, Yi-Ching Ho, Chia-Chun Chen, Feng-Huei Lin* and Hwa-Chang Liu* (2008, Jul). Chondrogenesis from immortalized human mesenchymal stem cells: comparison between collagen gel and pellet culture methods. Artificial Organs, 32(7): 561-566. (SCI)
45. Chih-Hung Chang, Hsu-Wei Fang*, Yi-Ching Ho, Huei-Ting Huang (2008, May). Chondrocyte acting as phagocyte to internalize polyethylene wear particles and leads to the elevations of osteoarthritis associated NO and PGE2. Biochemical and Biophysical Research Communications, 369(3): 884-888. (SCI)
46. Ming-Hsiao Hu, Wen-Chih Chen* and Chih-Hung Chang (2008, Jan). Idiopathic osteonecrosis of the third metacarpal head. Journal of the Formosan Medical Association, 107(1): 89-92. (SCI)
47. Chih-Hung Chang, Hsu-Wei Fang*, Huei-Ting Huang, Hsuan-Liang Liu, Wei-Ming Lee, Man-Ching Hsieh, Chiang-San Chen (2007, Jun). Tribological process induced conformational transformation of protein may change the friction of articular cartilage. Materials Letters, 61(16): 3381-3384. (SCI)
48. Hsu-Wei Fang*, Meng-Lin Shih, Jian-Hua Zhao, Huei-Ting Huan, Hsin-Yi Lin, Hsuan-Liang Liu, Chih-Hung Chang, Charng-Bin Yang, Hwa-Chang Liu (2007, Jun). Association of polyethylene friction and thermal unfolding of interfacial albumin molecules. Applied Surface Science, 253(16): 6896-6904. (SCI)
49. Charng-Bin Yang, Hsu-Wei Fang*, Hsuan-Liang Liu, Chih-Hung Chang, Man-Ching Hsieh, Wei-Ming Lee, Huei-Ting Huang (2006, Nov). Frictional characteristics of the tribological unfolding albumin for polyethylene and cartilage. Chemical Physicals Letters, 431(4-6): 380-384. (SCI)
50. Hsu-Wei Fang*, Charng-Bin Yang, Chih-Hung Chang, Chun-Hsiung Huang, Hsuan-Liang Liu, Shu-Bin Fang (2006, Nov). The Potential Role of Phagocytic Capacity in the Osteolytic Process Induced by Polyethylene Wear Particles. Journal of International Medical Research, 34(6): 655-664. (SCI)
51. Cheng-Hung Chou, Winston T. K. Cheng, Chien-Cheng Lin, Chih-Hung Chang, Chien-Chen Tsai and Feng-Huei Lin* (2006, May). TGF-beta1 immobilized tri-co-polymer for articular cartilage tissue engineering. Journal of Biomedical Materials Research: Part B, 77B (2): 338-348. (SCI)
52. Chih-Hung Chang, Tzong-Fu Kuo, Chien-Cheng Lin, Cheng-Hung Chou, Kuang-Ho Chen, Feng-Huei Lin* and Hwa-Chang Liua* (2006, May). Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin-chondroitin-hyaluronan tri-copolymer scaffold: A porcine model assessed at 18, 24, and 36 weeks. Biomaterials., 27(9): 1876-1888. (SCI)
53. Chih-Hung Chang, Feng-Huei Lin, Chien-Cheng Lin, Cheng-Hung Chou and Hwa-Chang Liu* (2004, Nov). Cartilage tissue engineering on the surface of a novel gelatin-calcium-phosphate biphasic scaffold in a double-chamber bioreactor. Journal of Biomedical Materials Research: Part B, 71(2):313-21. (SCI)
54. Chih-Hung Chang, Hwa-Chang Liu, Chien-Cheng Lin, Cheng-Hung Chou, Feng-Huei Lin* (2003, Nov). Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering. Biomaterials, 24(26): 4853-4858. (SCI)
55. Chih-Hung Chang, Kuang-Ho Chen, Rong-Sen Yang, Tang-Kue Liu (2002, May). Muscle Torques in Total Knee Arthroplasty with Subvastus and Parapatellar Approaches. Clinical orthopaedics and related research, 398: 189-195. (SCI)
56. J-S Sun, T T-F Shih, C-M Ko, Chih-Hung Chang, Y S Hang, S-M Hou. (2000) In Vivo Kinematic Study of Normal Wrist Motion: An Ultrafast Computed Tomographic Study. Clin Biomech 15:212-6. (SCI)
57. Chih-Hung Chang, Yi-Shiun Tsai, Jui-Sheng Sun, Sheng-Mou Hou (2000) Ipsilateral Distal Radius and Scaphoid Fractures. J Formos Med Assoc. 99: 733-7. (SCI)
58. Chih-Hung Chang and Shier-Chieg Huang: Clubfoot Deformity in Congenital Constriction Band Syndrome: Manifestations and Treatment (1998) J Formos Med Assoc 97:328-34. (SCI)
59. Chih-Hung Chang and Ching-Chuan Jiang (1997): Evaluation of Critical Postoperative Situations in Orthopedic Patients. J Formos Med Assoc 96: 990-5. (SCI)