現職

亞東紀念醫院醫學研究部 研究員 (2022.04-)

核心實驗室

再生醫學及細胞治療實驗室

經歷

骨骼再生與重建研究團隊 研究員

亞東紀念醫院骨科部 研究員

中央研究院基因體研究中心 博士後研究員 (2018-2020)

日本東京大學免疫學系 訪問學者 (2016-2018)

學歷

國立台灣大學免疫學所 博士

榮譽

☆ 2023: 15th Pan Pacific Symposium on Stem Cells and Cancer Research, PPSSC, Oral Presentation, US $2,000

☆ 2020: Foundation for the Advanced of Outstanding Scholarship: Traveling Expenses and Accommodation for the International Conference, US $3,000

☆ 2015: Ministry of Science and Technology: Postdoctoral Research Abroad Program (PRAP), US $87,000

專長領域

骨免疫學、組織再生、免疫學、動物疾病模式

專利

<Patent 1>

我方編號 FEH0001PRO

案件名稱(英) NEW APPROACH FOR CARTILAGE REGENERATION

申請人(中) 醫療財團法人徐元智先生醫藥基金會亞東紀念醫院申請人(英) FAR EASTERN MEMORIAL HOSPITAL

發明人(英) Hsiu-Jung Liao, Chih-Hung Chang, Yi-Shan Shen, Chi-Ying Huang

申請日期 2023/09/07 申請案號 63/581,085

 

<Patent 2>

我方編號 FEH0002PRO

案件名稱(英) METHOD AND PHARMACEUTICAL COMPOSITION FOR TREATING A CARTILAGE DAMAGE USING SOX9 GENE

申請人(中) 醫療財團法人徐元智先生醫藥基金會亞東紀念醫院,國立陽明交通大學

申請人(英) FAR EASTERN MEMORIAL HOSPITAL, National Yang Ming Chiao Tung University

發明人(英) Hsiu-Jung Liao, Chih-Hung Chang, Chi-Ying Huang ,Ly James Lee, Tai-Shan Cheng, Sin-Yu Chen, Andrew Stephen Lee

申請日期 2023/06/08 申請案號 63/506,917

 

<Patent 3>

我方編號 FEH0007PRO

案件名稱(英) METHOD AND PHARMACEUTICAL COMPOSITION FOR CARTILAGE REGENERATION

申請人(中) 醫療財團法人徐元智先生醫藥基金會亞東紀念醫院

申請人(英) FAR EASTERN MEMORIAL HOSPITAL

發明人(英) Hsiu-Jung Liao, Chih-Hung Chang, Yi-Shan Shen, Chi-Ying Huang

申請日期 2024/04/05 申請案號 63/575,293

個人著作

1. Hsiu-Jung Liao, Hui-Ting Chen, Chih-Hung Chang. (2024, Aug) Peptides for Targeting Chondrogenic Induction and Cartilage Regeneration in Osteoarthritis. Cartilage. (IF: 2.8)
2. Hsiu-Jung Liao, Yi-Ping Yang, Yu-Hao Liu, Huan-Chin Tseng, Teh-Ia Huo, Shih-Hwa Chiou, Chih-Hung Chang. (2024, Aug) Harnessing the potential of mesenchymal stem cells–derived exosomes in degenerative diseases. Regenerative Therapy. (IF: 3.4)
3. Hsiu-Jung Liao, Ping-Ning Hsu. (2024, May) Immunomodulatory effects of extracellular vesicles from mesenchymal stromal cells: Implication for therapeutic approach in autoimmune diseases. The Kaohsiung Journal of Medical Sciences. 1–10. (IF: 3.3)
4. I-Tsu Chyuan, Hsiu-Jung Liao, Tse-Hua Tan, Huai-Chia Chuang, Yu-Chuan Chu, Meng-Hsun Pan, Chien-Sheng Wu, Ching-Liang Chu, Bor-Ching Sheu and Ping-Ning Hsu. (2024, Mar) Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck. Journal of Biomedical Science. (IF: 10.9)
5. Sin-Yu Chen, Yi-Ling Chen, Po-Chen Li, Tai-Shan Cheng, Yeh-Shiu Chu, Yi-Shan Shen, Hsin-Tung Chen, Wei-Ni Tsai, Chien-Ling Huang, Martin Sieber, Yuan-Chieh Yeh, Hsiao-Sheng Liu, Chi-Ling Chiang, Chih-Hung Chang, Andrew S. Lee, Ly James Lee*, Hsiu-Jung Liao*, Hon-Kan Yip* and Chi-Ying F. Huang*. (2024, Mar) Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury. J Biomed Sci . 2024 Mar 19;31(1):30. doi: 10.1186/s12929-024-01019-4. (IF: 10.9)(連結)
6. Hung-Wei Chen, Chi-Hsiang Huang, Chi-Ying F. Huang, Chih-Hung Chang, Hsiu-Jung Liao*. (2023, Oct) Distinct subsets of synovial fibroblasts control cartilage destruction in joint diseases. Clin Exp Rheumatol . 2023 Sep 6. doi: 10.55563/clinexprheumatol/txl9rm. (IF: 3.7) (連結)
7. Yu-Chun Chen*, Hsiu-Jung Liao*, Yuan-Ming Hsu, Yi-Shan Shen, Chih-Hung Chang. (2022, Apr) Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model. Polymers (Basel), 5;14(7):1474. (IF: 5.0) (連結)
8. Chia-Yin Lee, Anh Thuc Nguyen, Ly Hien Doan, Li-Wei Chu, Chih-Hung Chang, Hui-Kang Liu, I-Lin Lee, Teng-Hsu Wang, Jin-Mei Lai, Shih-Ming Tsao, Hsiu-Jung Liao*, Yueh-Hsin Ping*, Chi-Ying F. Huang*. (2023 Feb) Repurposing Astragalus Polysaccharide PG2 for Inhibiting ACE2 and SARS-CoV-2 Spike Syncytial Formation and Anti-Inflammatory Effects. Viruses 2023, 15(3), 641; https://doi.org/10.3390/v15030641 (IF: 5.818) (連結)
9. Yu-Chen Tsai, Tai-Shan Cheng, Hsiu-Jung Liao, Ming-Hsi Chuang, Hui-Ting Chen, Chun-Hung Chen, Kai-Ling Zhang, Chih-Hung Chang, Po-Cheng Lin, Chi-Ying F. Huang (2022, Nov) Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation. Tissue Engineering and Regenerative Medicine 19:1295–1310. (IF: 4.169)(連結)
10. Ting-Hui Chang, Chien-Sheng Wu, Shih-Hwa Chiou, Chih-Hung Chang*, Hsiu-Jung Liao*, (2022, Jul) Adipose-Derived Stem Cell Exosomes as a Novel Anti-Inflammatory Agent and the Current Therapeutic Targets for Rheumatoid Arthritis. Biomedicines 2022 Jul 18;10(7):1725.doi: 10.3390/biomedicines10071725. (IF: 4.757)(連結)
11. Yu-Hung Chen, Hsiu-Jung Liao, Shang Ming Lin, Chih-Hung Chang, Syang-Peng Rwei, Tsung-Yu Lan (2022, June) Radiographic outcomes of the treatment of complex femoral shaft fractures (AO/OTA 32-C) with intramedullary nailing: a retrospective analysis of different techniques. Journal of International Medical Research, 50(6) 1–13. (IF: 1.36)
12. I-Tsu Chyuan, Ching-Liang Chu, Chia-Lang Hsu, Meng-Hsun Pan, Hsiu-Jung Liao, Chien-Sheng Wu, Ping-Ning Hsu. (2022 Mar) T Cell-Specific Deletion of TRAIL Receptor Reveals Its Critical Role for Regulating Pathologic T Cell Activation and Disease Induction in Experimental Autoimmune Encephalomyelitis. J Immunol. 2022 Apr 1;208(7):1534-1544. doi: 10.4049/jimmunol.2100788. (IF: 5.446)(連結)
13. Hsiu-Jung Liao, Ching-Liang Chu, Szu-Chieh Wang, Hua-Yi Lee, Chien-Sheng Wu. (2022) Increased HIF-1α expression in T cells and associated with enhanced Th17 pathway in systemic lupus erythematosus. Journal of the Formosan Medical Association 2022 May 19;S0929-6646(22)00188-7.doi: 10.1016/j.jfma.2022.05.003. (IF: 3.871)(連結)
14. Hsiu-Jung Liao, Chih-Hung Chang, Chi-Ying F. Huang, Hui-Tung Chen. (2022, Mar) Potential of Using Infrapatellar-Fat-Pad-Derived Mesenchymal Stem Cells for Therapy in Degenerative Arthritis: Chondrogenesis, Exosomes, and Transcription Regulation. Biomolecules 2022 Mar; 12(3): 386. (IF: 6.064)(連結)
15. Chiao-Feng Cheng, Hsiu-Jung Liao, Chien-Sheng Wu. (2022, Feb) Tissue microenvironment dictates inflammation and disease activity in rheumatoid arthritis. Journal of the Formosan Medical Association. (IF: 3.871)(連結)
16. Hsiu-Jung Liao, Hwei-Fang Tsai, Chien-Sheng Wu, I-Tsu Chyuan, Ping-Ning Hsu (2019, Jan). TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment. Cell Death and Disease, 10(2):77. (IF: 9.705) (連結)
17. I-Tsu Chyuan, Hwei-Fang Tsai, Hsiu-Jung Liao, Chien-Sheng Wu, Ping-Ning Hsu (2018, Sep). An apoptosis-independent role of TRAIL in suppressing joint inflammation and inhibiting T-cell activation in inflammatory arthritis. Cellular Molecular Immunology, 15(9):846-857. (IF: 22.096)(連結)
18. Hwei-Fang Tsai, Chien-Sheng Wu, Yi-Lin Chen, Hsiu-Jung Liao, I-Tsu Chyuan, Ping-Ning Hsu (2016, May). Galectin-3 suppresses mucosal inflammation and reduces disease severity in experimental colitis. Journal of Molecular Medicine (Berl), 94(5):545-56. (IF: 5.606) (連結)
19. Hsiu-Jung Liao, I-Tsu Chyuan, Chien-Sheng Wu, Shu-Wha Lin, Kun-Hug Chen, Hwei-Fang Tsai, Ping-Ning Hsu. (2015, Jan). Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice. Rheumatology (Oxford), 54(7), 1317-1326. MOST 98-2320-B-002-049-MY3. (IF: 7.046)(連結)
20. Horng-Tay Tzeng, Hwei-Fang Tsai, I-Tsu Chyuan, Hsiu-Jung Liao, Chun-Jen Chen, Pei-Jer Chen, Ping-Ning Hsu (2014, Jul). Tumor necrosis factor-alpha induced by hepatitis B virus core mediating the immune response for hepatitis B viral clearance in mice model. PLoS One, 21;9(7): e103008. (IF: 3.752)(連結)
21. Wei-Chang Lin, Hwei-Fang Tsai, Hsiu-Jung Liao, Chen-Hsi Tang, Yi-Ying Wu, Ping-I Hsu, Ann-Lii Cheng, Ping-Ning Hsu (2014, Mar). Helicobacter pylori sensitizes TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric epithelial cells through regulation of FLIP. Cell Death and Disease, 6;5: e1109. MOST 102-2320-B-038-040-MY3. (IF:9.705)(連結)
22. Shu-Chun Chuang, Hsiu-Jung Liao, Ching-Ju Lia, Gwo-Jaw Wang, Je-Ken Chang, Mei-Ling Ho (2013, Aug). Simvastatin enhances human osteoblast proliferation involved in mitochondrial energy generation. European Journal of Pharmacology, 714(1-3):74-82. NSC 94-2314-B-037-023. (IF: 5.195)(連結)
23. Horng-Tay Tzeng, Hwei-Fang Tsai, Hsiu-Jung Liao, Yi-Jiun Lin, Lie-ping Chen, Pei-Jer Chen, Ping-Ning Hsu (2012, Jun). PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model. PLoS One, 7(6): e39179. (IF: 3.752) (連結)
24. Men-Luh Yen, Ping-Ning Hsu, Hsiu-Jung Liao, Be-Han Lee, Hwei-Fang Tsai (2012, Jun). TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation. PLoS One, 7(6): e38048. (IF: 3.752) (連結)
25. Shih-Chia Huang, Hwei-Fang Tsai, Horng-Tay Tzeng, Hsiu-Jung Liao, Ping-Ning Hsu (2011, Jan). Lipid raft assembly and Lck recruitment in TRAIL costimulation mediates NF-κB activation and T cell proliferation. Journal of Immunology, 186(2):931-9. 經濟部: NHRI-EX95-9532SI. (IF:5.446) (連結)
26. Je-Ken Chang, Ching-Ju Li, Hsiu-Jung Liao, Chih-Kuang Wang, Gwo-Jaw Wang, Mei-Ling Ho (2009, Apr). Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. Toxicology, 258(2-3):148-56. 經濟部: NHRI-EX97-9615EP. (IF: 4.571) (連結)
27. Mei-Ling Ho, Yi-Huei Chen, Hsiu-Jung Liao, Chung-Hwan Chen, Shao-Hung Hung, Mon-Juan Lee, Yin-Chih Fu, Yan-Hsiung Wang, Gwo-Jaw Wang, Je-Ken Chang (2009, Apr). Simvastatin increases osteoblasts and osteogenic proteins in ovariectomized rats. European Journal of Clinical Investigation, 39(4):296-303. NSC 93-2314-B-037-053. (IF: 5.722)(連結)
28. 廖秀蓉,張至宏,黃奇英（2023年09月）。再生醫療雙法草案遭遇卡關？台灣再生醫療發展面臨的爭議與挑戰。科學月刊，501期。(本人為第一作者)
29. 廖秀蓉（2022年05月）。脂肪幹細胞分泌外泌體之免疫調控-以類風濕性關節炎之無細胞治療為例。景福醫訊，39(5), 11-13. (本人為第一作者)
30. 張至宏,廖秀蓉（2021年09月）。從退化性關節炎看<特管法>的個案審查。科學月刊，621(9), 16-21. (本人為第一作者)
31. 張至宏,廖秀蓉,雷涵?,陳郁君（2021年04月）。退化性關節炎與軟骨缺損的再生醫學治療。高雄醫師會誌，29(1),72-81.

Invited Speaker

1. Hsiu-Jung Liao, (2023, Nov., 8) Encapsulation of Therapeutic mRNA in Extracellular Vesicles for the Treatment of Osteoarthritis, Asian Federation for Pharmaceutical Sciences (AFPS), Hanoi, Viet Nam.
2. Hsiu-Jung Liao, (2024, Apr., 22) Intraarticularly delivery mRNA-encapsulating extracellular vesicles for osteoarthritis therapy, China Medical University, Taiwan.
3. Hsiu-Jung Liao, (2024, Jun., 29) Intra-articular Delivery of mRNA-Encapsulated Extracellular Vesicles for Osteoarthritis Treatment, TORS & CAOS International Conference, Taiwan.
4. Hsiu-Jung Liao, (2024, Oct., 22) Extracellular vesicles in knee osteoarthritis, National Biotechnology Research Park, Taiwan.
5. Hsiu-Jung Liao, (2024, Nov., 17) Extracellular vesicles in knee osteoarthritis, The Pharmacogenomics Society of Taiwan, Taiwan.
6. Hsiu-Jung Liao, (2024, Nov., 23) New Approach for Cartilage Regeneration, 2024 台灣細胞醫療協會年會, Taipei, Taiwan.