角膜再生與創傷癒合研究團隊

Corneal Regeneration and Wound Healing Research Team

 

最新消息

    本團隊主持人張淑雯副院長—

1. "Association between Dry Eye Parameters Depends on Tear Components."之研究成果刊登於國際期刊 Journal of Clinical Medicine (2022.05.28).

2. "Dermatochalasis Aggravates Meibomian Gland Dysfunction Related Dry Eyes"之研究成果刊登於國際期刊 Journal of Clinical Medicine (2022.04.23).

3. "Repeated cell sorting ensures the homogeneity of ocular cell populations expressing a transgenic protein"之研究成果刊登於國際期刊 PLoS ONE (2022.03.25).

  研究內容

將初代培養的角膜基質細胞，透過體外培養的方式改造體細胞，尋求能促使角質細胞的前趨細胞進行大量增生的生長條件，使其可增生成新的類角膜基質細胞，以重建受傷的角膜。 研究於角膜屈光手術過程中，所用的藥物及其濃度對角膜上皮細胞及基質細胞的影響及作用機轉。利用角膜基質細胞的初步培養方法及分子生物學的相關技術，分析角膜細胞在藥物處理之後所產生的分子反應，藉以瞭解其對手術後角膜在傷口癒合過程可能造成的影響。

  團隊成員

團隊主持人    張淑雯 副院長(Dr. Shu-Wen Chang)

眼科醫師      何威廷 博士 (Dr. Wei-Ting Ho)

眼科醫師      黃子倫 博士 (Dr. Tzu-Lun Huang)

眼科醫師      張珮瑤 醫師 (Dr. Pei-Yao Chang)

眼科醫師      蔡紫筠 醫師 (Dr. Tzu-Yun Tsai)

研究員        陳燦麒 博士 (Dr. Tsan-Chi Chen)

臨床專護      李祥瑜 (Miss Siang-Yu Li)

研究助理      張鳳君 (Miss Feng-Chun Chang)

  合作單位

國立陽明大學　生醫光電與超音波實驗室

江惠華 教授　(Dr. Huihau-Kenny Chiang)

 

元智大學　電機工程學系生醫系統實驗室

蘇泰元 副教授　(Dr. Tai-Yuan Su)

  論文發表 (2021 JCR)

  會議海報

  研究成果

• Repeated cell sorting ensures the homogeneity of ocular cell populations expressing a transgenic protein. (PLoS ONE, 2022)

 

 

• The role of intracellular ZO-1, PKCε, and Rac-1 during MOX-modulated random migration in corneal fibroblasts. (European Journal of Pharmacology, 2021)

 

 

• Construction of a NOST model (Ocular Surface, 2020)

 

 

• The role of intracellular MMP9 during MMC retardation of corneal fibroblast migration (European Journal of Pharmacorlogy, 2019)

 

• TGF-β1 induction of IL-12 Secretion in the isolated HCFs (Investigative Ophthalmology & Visual Science, 2017)

• Inhibition of ciprofloxacin and moxifloxacin in human corneal motility via reducing the binding affinity of paxillin to FAK (Experimental Eye Research, 2016)

 

• The ocular surface thermograph. Thermography captures the ocular surface thermographic image in a non-invasive manner. (British Journal of Ophthalmolgoy, 2014)

 

 

• Feasibility of using the noncontact thermograph method to evaluate tear film stability without using a fluorescein sodium drop (Biomedical Optics Express, 2014)

 

 

• A Beneficial Postoperative Dexamethasone Treatment following Intraoperative Mitomycin C Application (Experimental Eye Research, 2014)

 

 

• Anit-Fibrotic Efficiency of Moxifloxacin in Human Corneal Fibroblasts (British Journal of Pharmacorlogy, 2013)

 

 

• Suppression of Mitomycin C during Cell Migration of Human Corneal Fibroblasts (Investigative Ophthalmology & Visual Science, 2012)

 

 

• Indirect Regulation of Mitomycin C during Corneal Epithelial Migration (Investigative Ophthalmology & Visual Science, 2010)

 

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